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Prevention of peripheral side-effects of transdermal hyoscine by adjunctive therapy with low dosage of pyridostigmine.

Author: AlhalelA, AlkalayM, AlmogS, IzraeliS, MenahemS, RuachM, TochnerZ, VersanoD, ZivI

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Low-dose pyridostigmine effectively prevented the peripheral anti-muscarinic side effects of transdermal hyoscine in 47 healthy subjects. Pyridostigmine may increase the tolerability of transdermal hyoscine therapy.
Paper Details　
Original Abstract of the Article :
1. The value of low dosage of pyridostigmine (30 mg three times daily) in preventing peripheral anti-muscarinic side effects of a transdermal controlled-release formulation of hyoscine, was tested in a double-blind placebo-controlled study, involving 47 healthy subjects. 2. Salivary excretion was re...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1992.tb04078.x

データ提供：米国国立医学図書館（NLM）

Preventing Side Effects of Transdermal Hyoscine: A Novel Approach

Transdermal hyoscine, a medication used to treat motion sickness and other conditions, can sometimes cause unwanted side effects. This research, like a camel caravan seeking a way to mitigate the challenges of a harsh desert environment, explores the use of pyridostigmine to prevent these side effects.

A Strategic Approach to Side Effect Management

The authors conducted a double-blind, placebo-controlled study to investigate the effectiveness of pyridostigmine in preventing the peripheral anti-muscarinic side effects of transdermal hyoscine. They found that low doses of pyridostigmine were effective in reducing the incidence of side effects, offering a potential solution for individuals experiencing these challenges. This approach is like a camel caravan using a strategic route to avoid obstacles and minimize the risk of danger.

Improving Patient Comfort

This research highlights the importance of finding ways to minimize the side effects of medications and improve patient comfort. It's a testament to the ongoing quest for safer and more effective treatment options, much like the camel, through its adaptability and resilience, has evolved to thrive in harsh desert environments.

Dr.Camel's Conclusion

This research suggests that pyridostigmine may be a valuable tool in preventing the side effects of transdermal hyoscine. The study underscores the importance of finding ways to optimize medication regimens and improve patient experiences.

Date :
  1. Date Completed 1992-10-19
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

1524963

DOI: Digital Object Identifier

10.1111/j.1365-2125.1992.tb04078.x

Related Literature

Article Analysis
・Side Effects of pyridostigmine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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