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[New drugs for the treatment of human parasitic protozoa].

Author: Dupouy-CametJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The study discusses the progress made in the treatment of intestinal protozoa, malaria, visceral leishmaniasis, and toxoplasmosis. It highlights the development of new drugs, such as nitazoxanide for intestinal protozoa, artemisinin derivatives for malaria, and miltefosine for visceral leishmaniasis. It also emphasizes the importance of continued research to develop new antiprotozoan molecules due to drug resistance and lack of safe and effective treatment options for pregnant women and children.
Paper Details　
Original Abstract of the Article :
Whereas parasitic diseases are always a heavy burden for humanity, few are the new antiparasitic molecules marketed during the last 25 years. Thus on the 1393 new molecules marketed between 1975 and 1999, only 7 have antiprotozoan properties. This talk will detail the progress made in the treatment ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15305692

データ提供：米国国立医学図書館（NLM）

New Drugs for the Treatment of Parasitic Protozoa: A Desert Oasis of Hope

Parasitic diseases are a persistent thorn in humanity's side, causing untold suffering and hindering development. This study delves into the challenging world of antiparasitic drug development, exploring the progress made in treating a range of parasitic protozoa, including intestinal protozoa, malaria, visceral leishmaniasis, and toxoplasmosis. The researchers review the latest advances in drug discovery, highlighting promising new molecules and strategies for combating these debilitating diseases.

A Steady Progress in Antiparasitic Drug Development

Despite the daunting challenge, the study showcases significant progress in the development of new antiparasitic drugs. The researchers highlight the introduction of new drugs for treating intestinal protozoa, such as nitazoxanide, which is effective against a broad spectrum of parasites and has a favorable safety profile. The study also emphasizes the advancements in malaria treatment with the development of artemisinin derivatives, which have proven effective against drug-resistant strains of the parasite. The researchers also explore the potential of new drugs for treating visceral leishmaniasis, including miltefosine, which has shown promise in treating drug-resistant cases.

The Ongoing Quest for New Antiparasitic Drugs

The study acknowledges that the fight against parasitic diseases is far from over. The emergence of drug resistance and the lack of effective treatments for certain parasitic stages remain significant challenges. The researchers urge continued research and development to address these challenges, highlighting the need for a multidisciplinary approach involving scientists, clinicians, and public health experts.

Dr.Camel's Conclusion

This study is like a refreshing oasis in the vast desert of parasitic diseases. While the challenges remain, the progress in developing new drugs offers hope for a brighter future. By embracing innovation and collaboration, we can continue to push the boundaries of antiparasitic drug development and ultimately create a world free from the scourge of these debilitating diseases.

Date :
  1. Date Completed 2004-10-12
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

15305692

DOI: Digital Object Identifier

15305692

SNS
PICO Info
in preparation
Languages

French

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