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Regeneration of the heart in diabetes by selective copper chelation.

Author: AllenGrant R, BakerJohn R, BorgThomas K, BoydPeter D W, BruntonDianne H, ChanYih-Kai, ChoongSoon Y, CooperGarth J S, CowanBrett R, CrossmanDavid J, DissanayakeAjith M, DoughtyRobert N, GambleGregory D, KeoghGeraldine F, LeahyFiona E, LeonardBridget L, OccleshawChristopher J, PhillipsAnthony R J, PopeAdèle J, PoppittSally D, Saafi'Etuate L, YoungAlistair A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that administration of the Cu-selective transition metal chelator trientine to rats with streptozotocin-induced diabetes caused increased urinary Cu excretion. In diabetic animals with established heart failure, 7 weeks of oral trientine therapy significantly alleviated heart failure, substantially improved cardiomyocyte structure, and reversed elevations in left ventricular collagen and beta(1) integrin. Oral trientine treatment also caused elevated Cu excretion in humans with type 2 diabetes.
Paper Details　
Original Abstract of the Article :
Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Although altered systemic regulation of transition metals in diabetes has been the subject of previous investigation, it is not known whether changed transition ...See full text at original site
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引用元：
https://doi.org/10.2337/diabetes.53.9.2501

データ提供：米国国立医学図書館（NLM）

Copper Chelation: A New Approach to Treating the Heart in Diabetes

This research explores a novel approach to treating heart disease in diabetes, focusing on the role of copper chelation. The study investigates the effects of trientine, a copper-selective chelator, on diabetic rats with established heart failure. This research is like a desert oasis, offering a refreshing perspective on the complex interplay between diabetes and heart disease. The researchers used streptozotocin-induced diabetes in rats to mimic the human condition. It's like creating a miniature desert environment to study the intricacies of the disease.

Copper Chelation: A Potential Solution for Cardiac Damage in Diabetes

The study found that trientine therapy significantly alleviated heart failure in diabetic rats, improving cardiomyocyte structure and reversing the buildup of collagen and beta(1) integrin in the heart. It's like finding a hidden spring in the desert, restoring vitality to a damaged heart. The study also showed that trientine led to elevated copper excretion in humans with type 2 diabetes. This suggests that copper accumulation may contribute to cardiac damage in diabetes. This research is like a desert expedition, revealing the hidden pathways of the disease.

Copper Chelation: A Promising New Avenue for Diabetes Management

This research suggests that copper chelation could be a valuable addition to the arsenal of treatments for heart disease in diabetes. It's like discovering a new oasis in the desert of diabetes research, offering a potentially effective and well-tolerated treatment option. This research paves the way for future investigations into the role of copper chelation in managing diabetes-related complications.

Dr.Camel's Conclusion

This study sheds light on a potentially new pathway for treating heart disease in diabetes. It's a testament to the ongoing search for novel solutions to complex medical challenges. This research reminds us that even the smallest details, like copper accumulation, can have significant implications for human health. By understanding these details, we can develop more effective treatments and improve the lives of millions worldwide.

Date :
  1. Date Completed 2004-10-26
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

15331567

DOI: Digital Object Identifier

10.2337/diabetes.53.9.2501

SNS
PICO Info
in preparation
Languages

English

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