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Resistance profiles and adherence at primary virological failure in three different highly active antiretroviral therapy regimens: analysis of failure rates in a randomized study.

Author: BarfodT S, GerstoftJ, KatzensteinT L, KirkO, LundgrenJ D, MathiesenL R, NielsenH, ObelN, PedersenC, RøgeB T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Treatment interruption or poor adherence was the main cause of primary virological failure in patients on highly active antiretroviral therapy (HAART). Resistance mutations were prevalent in patients failing on regimens containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) and nucleoside reverse transcriptase inhibitors (NRTIs), but not in those failing on boosted saquinavir.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To investigate the interplay between resistance and adherence in the virological failure of three fundamentally different highly active antiretroviral therapy (HAART) regimens. METHODS: We retrospectively identified 56 verified primary virological failures (viral load >400 HIV-1 RNA cop...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15369509

データ提供：米国国立医学図書館（NLM）

Highly Active Antiretroviral Therapy (HAART): Exploring Resistance and Adherence in Treatment Failure

The development of highly active antiretroviral therapy (HAART) has revolutionized the treatment of HIV infection. This study delves into the complex interplay of resistance and adherence in the context of virological failure of three distinct HAART regimens. The authors analyzed data from a randomized trial involving 293 patients, identifying 56 primary virological failures (viral load >400 HIV-1 RNA copies/mL) and exploring factors contributing to treatment failure.

Adherence and Resistance: Key Determinants of Treatment Success

The study findings reveal that treatment interruption or poor adherence, primarily driven by side effects, accounted for 74% of virological failures. In contrast, resistance mutations were more common in patients who continued their assigned treatment, suggesting that both adherence and resistance play crucial roles in treatment success. Specifically, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) and nucleoside reverse transcriptase inhibitors (NRTIs) was prevalent in patients failing on regimens based on these medications.

Navigating the Desert of HIV Treatment

Managing HIV infection can be a challenging journey, much like navigating a vast desert with shifting sands. This study highlights the importance of both medication adherence and understanding resistance patterns. By addressing these factors, clinicians can better guide patients towards a more successful and sustainable treatment path.

Dr.Camel's Conclusion

This research provides valuable insights into the factors influencing virological failure in patients receiving HAART. The authors emphasize the critical roles of adherence and resistance in treatment outcomes, offering a reminder that success requires a multi-faceted approach. Their findings serve as a compass, guiding clinicians towards a deeper understanding of the complexities of HIV treatment and the need for personalized care strategies.

Date :
  1. Date Completed 2004-11-24
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

15369509

DOI: Digital Object Identifier

HIV233

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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