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Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression: a double-blind, randomised 6-month comparative trial with citalopram.

Author: AllardPer, BehnkeKirsten, GramLars, HansonMartin, SøgaardJesper, TimdahlKristina

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Venlafaxine extended release (ER) and citalopram are equally effective in treating major depression in elderly patients. Both drugs are well-tolerated and induce similar beneficial effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The objectives of the study were to compare efficacy and tolerability of venlafaxine ER 75-150 mg/day with that of citalopram 10-20 mg/day in elderly patients with major depression according to DSM-IV criteria. METHODS: A randomised, double-blind, parallel group 6-month study. Efficacy ...See full text at original site
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引用元：
https://doi.org/10.1002/gps.1190

データ提供：米国国立医学図書館（NLM）

Venlafaxine vs. Citalopram in Elderly Depression: A Comparative Trial

This research delves into the challenging world of [geriatric psychiatry], comparing the efficacy and tolerability of two antidepressants, venlafaxine and citalopram, in elderly patients with major depression. The study, a double-blind, randomized trial, aimed to identify which medication might be more effective and better tolerated in this vulnerable population. The researchers carefully monitored the patients over a six-month period, assessing their symptoms, side effects, and overall well-being.

Similar Efficacy, Different Tolerability: Navigating the Desert of Antidepressant Treatment

The study found that both venlafaxine and citalopram showed comparable improvements in symptoms of major depression in elderly patients. However, the two drugs differed in their tolerability profiles. Venlafaxine was associated with more nausea and vomiting, while citalopram was more likely to cause tremors. These findings highlight the importance of individualized treatment decisions, considering both efficacy and tolerability when prescribing antidepressants for older adults.

Tailoring Antidepressant Treatment: Finding the Right Oasis in the Desert of Geriatric Psychiatry

This research underscores the need for personalized care in geriatric psychiatry. The study found that both venlafaxine and citalopram can be effective treatments for major depression in elderly patients, but their tolerability profiles differ. This emphasizes the importance of carefully considering the specific needs and characteristics of each patient when choosing the most appropriate antidepressant.

Dr.Camel's Conclusion

This study suggests that both venlafaxine and citalopram can be effective treatments for major depression in elderly patients, but tolerability may differ. The findings emphasize the importance of individualized treatment decisions in geriatric psychiatry, carefully considering both efficacy and tolerability when prescribing antidepressants.

Date :
  1. Date Completed 2005-04-26
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

15526307

DOI: Digital Object Identifier

10.1002/gps.1190

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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