Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis.

Author: ArastehKeikawus, BornerKlaus, BushrabFaris Nadiem, DunayIldiko R, FitznerRudolf, HeimesaatMarkus M, KurowskiMichael, LiesenfeldOliver, MüllerRainer H, StockerHartmut

Paper Details 
Original Abstract of the Article :
Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is hampered ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC529229/

データ提供:米国国立医学図書館(NLM)

A New Oasis: Atovaquone for Preventing Reactivation of Toxoplasmic Encephalitis

Toxoplasmic encephalitis (TE), a serious brain infection caused by the parasite *Toxoplasma gondii*, can be life-threatening, especially in individuals with weakened immune systems. This study, like a desert expedition searching for a new water source, investigates the potential of atovaquone, an antiparasitic drug, as a maintenance therapy to prevent the reactivation of TE. The researchers conducted a study in mice with a genetic predisposition to developing reactivated TE. They found that atovaquone, when administered orally, effectively prevented the reactivation of TE and death. The researchers concluded that atovaquone appeared superior to the standard maintenance therapy regimens in this murine model, suggesting its potential as a promising alternative treatment for TE. They emphasized the need for further clinical trials to confirm these findings in humans.

A Promising Alternative: Atovaquone for TE Maintenance Therapy

This study offers a glimmer of hope for individuals at risk of reactivating TE. The researchers' findings suggest that atovaquone may be a viable alternative to the current standard maintenance therapy, which is often associated with significant side effects. The study's results are particularly encouraging given the unmet need for safer and more effective treatments for TE.

Navigating the Desert of Infection: New Horizons in Treatment

This study, like a beacon guiding travelers through a treacherous desert, highlights the importance of exploring new frontiers in medicine. The researchers' discovery of atovaquone's potential as a maintenance therapy for TE provides a promising avenue for combating this challenging infection.

Dr.Camel's Conclusion

This study, like a caravan traversing a vast desert, reminds us that the pursuit of new knowledge is essential in the fight against disease. The researchers' groundbreaking findings offer a new oasis of hope for those battling TE, emphasizing the importance of continuous exploration and innovation in the pursuit of better treatments.

Date :
  1. Date Completed 2005-01-18
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

15561866

DOI: Digital Object Identifier

PMC529229

Related Literature

SNS
PICO Info
in preparation
Languages

English

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