The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults.

Author: CurrieAlexander, FiedorekFred T, GraselaDennis M, HaasDavid W, HodderSally L, NoorMustafa A, O'MaraEdward, ParkerRex A

Paper Details 
Original Abstract of the Article :
Therapy with some HIV protease inhibitors (PI) contributes to insulin resistance and type 2 diabetes mellitus, by inhibition of insulin-sensitive glucose transporters. Atazanavir (ATV) is a new PI with substantially less in vitro effect on glucose transport than observed with other PI, including lop...See full text at original site
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引用元:
https://doi.org/10.1097/00002030-200411050-00005

データ提供:米国国立医学図書館(NLM)

HIV Protease Inhibitors and Insulin Sensitivity

In the world of HIV treatment, like a vast desert teeming with hidden dangers, some medications can have unintended consequences. This study investigates the impact of HIV protease inhibitors (PIs) on insulin sensitivity, a vital aspect of glucose regulation, much like a camel's ability to store and utilize water in the harsh desert environment.

The authors examined the effects of two PIs, atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV), on insulin sensitivity in healthy individuals who don't have HIV. Some PIs can contribute to insulin resistance, similar to a camel struggling to access water due to a blocked oasis. The research found that ATV, a newer PI, had a significantly less negative impact on glucose transport compared to LPV/RTV, suggesting a potentially safer option for managing HIV.

Navigating the Challenges of HIV Treatment

This study highlights the importance of understanding the potential side effects of medications, particularly in the context of complex conditions like HIV. It underscores the need to carefully consider the individual needs of each patient and choose treatments that minimize risks while maximizing benefits, just as a skilled camel driver selects the safest and most efficient path across the desert.

Understanding the Impact on Health

The study's findings offer valuable insights into the potential impact of HIV treatment on glucose regulation. This knowledge empowers healthcare professionals to make informed decisions about medication choices and to monitor patients for any potential changes in insulin sensitivity, ensuring their overall health and well-being is maintained.

Dr.Camel's Conclusion

Treating HIV is like navigating a treacherous desert, requiring careful planning and vigilance. This research sheds light on the potential impact of PIs on insulin sensitivity, emphasizing the importance of choosing treatments that minimize risks and optimize long-term health outcomes. By navigating the complexities of HIV management, healthcare professionals can help patients navigate their own personal deserts.

Date :
  1. Date Completed 2005-03-29
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

15577646

DOI: Digital Object Identifier

10.1097/00002030-200411050-00005

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Languages

English

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