Paper Details

  1. Home
  2. Paper Details

Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists.

Author: KaneKathleen A, PauDavide, RankinAndrew C, WorkmanAntony J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of prucalopride, a 5-HT4 receptor agonist, on human atrial myocytes. Prucalopride increased I(CaL) and APD50, but did not affect late repolarization, refractory period, or induce arrhythmia, suggesting a relatively safe profile.
Paper Details　
Original Abstract of the Article :
Prucalopride is a selective 5-hydroxytryptamine type 4 (5-HT4) receptor agonist developed for the treatment of gastrointestinal disorders. The endogenous agonist 5-HT acting via 5-HT4 receptors increases the L-type Ca2+ current (I(CaL)) with potentially proarrhythmic consequences (Pau et al., 2003)....See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1124/jpet.104.076869

データ提供：米国国立医学図書館（NLM）

The Curious Case of Prucalopride: A Look at its Electrophysiological Effects

The heart is a remarkable organ, beating tirelessly to pump blood throughout the body. This study delves into the electrophysiological effects of prucalopride, a drug used to treat gastrointestinal disorders, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists. The authors investigate the potential impact of prucalopride on heart rhythm, exploring its effects on calcium currents and action potentials.

A Balancing Act: Effects on Calcium Currents and Action Potentials

The research shows that prucalopride, at therapeutic concentrations, has minimal effects on calcium currents and action potentials in human atrial myocytes. This suggests that prucalopride is unlikely to significantly disrupt heart rhythm, even in patients taking beta-adrenoceptor antagonists. It's like finding a delicate balance between the forces of nature, where the effects of prucalopride on heart rhythm are carefully controlled and maintained.

Navigating the Landscape: Understanding Potential Risks

The authors highlight the importance of understanding the potential electrophysiological effects of prucalopride, particularly in patients taking beta-adrenoceptor antagonists. This emphasizes the need for careful monitoring and a holistic approach to managing patients, considering the potential interactions between different medications. It's like navigating a vast and complex desert landscape, carefully assessing the potential risks and opportunities along the way.

Dr.Camel's Conclusion

This study provides valuable insights into the electrophysiological effects of prucalopride, highlighting its minimal impact on heart rhythm. It underscores the importance of careful monitoring and a holistic approach to managing patients, considering the potential interactions between different medications. Like a seasoned camel guide, we must carefully navigate the complexities of medication interactions, ensuring the safety and well-being of our patients.

Date :
  1. Date Completed 2005-05-19
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

15644433

DOI: Digital Object Identifier

10.1124/jpet.104.076869

Related Literature

Article Analysis
・Effects of prucalopride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.