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Recombinant growth hormone therapy for X-linked hypophosphatemia in children.

Author: ChaominW, HuimingY

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Standard treatment for X-linked hypophosphatemia, a condition that affects phosphate levels and bone health, involves taking phosphate and vitamin D. While this can improve rickets, it doesn't always significantly raise phosphate levels or normalize growth. Some studies suggest that adding growth hormone to standard treatment improves growth rate, phosphate retention, and bone density. However, other studies suggest that growth hormone may worsen the pre-existing height differences in these children.
Paper Details　
Original Abstract of the Article :
Conventional treatment of X-linked hypophosphatemia with oral phosphate and calcitriol can heal rickets, but it does not always raise serum phosphate concentrations significantly, nor does it always normalize linear growth. Some clinical trials suggest that combining recombinant human growth hormone...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD004447.pub2

データ提供：米国国立医学図書館（NLM）

X-Linked Hypophosphatemia: A Complex Journey of Growth and Development

The world of human growth and development is a complex and fascinating desert, filled with intricate pathways and challenges. This study, published in the journal Journal of Clinical Endocrinology & Metabolism, examines the use of recombinant growth hormone therapy in children with X-linked hypophosphatemia, a rare genetic disorder that affects bone growth and development. This research aims to understand the potential benefits and risks of growth hormone therapy in this specific population.

Growth Hormone Therapy: A Potential Solution for X-Linked Hypophosphatemia?

The study suggests that growth hormone therapy may be a valuable addition to conventional treatment for X-linked hypophosphatemia, potentially improving growth velocity and bone mineral density. However, it also highlights the potential for growth hormone therapy to exacerbate pre-existing disproportionate stature. This emphasizes the need for careful monitoring and individualized treatment plans when considering growth hormone therapy for children with X-linked hypophosphatemia.

Navigating the Challenges of Growth and Development

This research underscores the importance of a multidisciplinary approach when managing X-linked hypophosphatemia. Careful monitoring of growth, bone mineral density, and potential side effects is crucial for ensuring the best possible outcome for children with this rare genetic disorder.

Dr. Camel's Conclusion

This study provides valuable insights into the use of growth hormone therapy for X-linked hypophosphatemia. While it offers potential benefits for improving growth and bone health, careful monitoring and individualized treatment plans are essential to ensure the best possible outcomes for children with this complex condition. We need to continue to explore and understand the nuances of this rare genetic disorder and develop effective treatment strategies that address the unique challenges faced by individuals with X-linked hypophosphatemia.

Date :
  1. Date Completed 2005-05-27
  2. Date Revised 2021-11-05
Further Info :

Pubmed ID

15674949

DOI: Digital Object Identifier

10.1002/14651858.CD004447.pub2

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in preparation
Languages

English

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