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High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia.
Author: BartensteinPeter, BuchholzHans-Georg, GründerGerhard, HiemkeChristoph, HärtterSebastian, RöschFrank, SiessmeierThomas, StoeterPeter, VernalekenIngo
Original Abstract of the Article :
The 'atypicality' of the antipsychotic drug, amisulpride, has been attributed to preferential extrastriatal binding. Previous investigations of striatal D2 receptor occupancy by amisulpride revealed conflicting results. The aim of this PET study was to measure the striatal occupancy by amisulpride a...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1017/S1461145704004353
データ提供:米国国立医学図書館(NLM)
The Desert of Schizophrenia: Seeking Effective Treatments
The desert of schizophrenia is a challenging landscape, marked by complex symptoms and a need for effective treatments. This research explores the effectiveness of amisulpride, an atypical antipsychotic, in treating this condition.
The researchers, like desert explorers seeking a source of relief, investigate the striatal occupancy of D2-like dopamine receptors by amisulpride in patients with schizophrenia. They use PET imaging to measure the levels of amisulpride binding to these receptors in the brain, aiming to understand the relationship between drug concentrations and therapeutic effects.
The Oasis of Amisulpride: Understanding Its Effects
This research reveals that amisulpride can achieve high levels of striatal D2-like receptor occupancy in patients with schizophrenia. This finding suggests that amisulpride, even at lower doses, can effectively target the dopamine system, which is believed to play a role in the symptoms of schizophrenia. It’s like finding a hidden oasis with a rich source of water, capable of sustaining life even in the most arid environments.
Navigating the Desert of Schizophrenia: Finding Effective Therapies
This research highlights the potential of amisulpride as an effective treatment for schizophrenia. It’s a reminder that even in the vast and often challenging desert of mental illness, there are often oases of hope waiting to be discovered.
Dr. Camel's Conclusion
This research, like a journey through a desert of complex mental illness, provides valuable insights into the effectiveness of amisulpride in treating schizophrenia. It's a reminder that even in the most challenging landscapes, there are often hidden oases of knowledge waiting to be discovered.
Date :
- Date Completed 2005-02-24
- Date Revised 2018-12-01
Further Info :
Related Literature
English
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