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Multicenter, randomized study of the effectiveness of basiliximab in avoiding addition of steroids to cyclosporine a monotherapy in renal transplant recipients.

Author: AndrewsChristopher D, HammadAbdel Q, LodgeJ Peter A, ParrottNeil R, WatsonChristopher J E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Basiliximab significantly reduces the need for additional immunosuppression in renal transplant recipients receiving steroid-free cyclosporine A (CsA) therapy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Steroid therapy is associated with an increased risk of cardiovascular events and well-documented adverse effects, but two thirds of patients initiated on monotherapy with cyclosporine A (CsA) microemulsion require addition of steroids. METHODS: In this 12-month randomized, double-blind...See full text at original site
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引用元：
https://doi.org/10.1097/01.tp.0000151006.86197.76

データ提供：米国国立医学図書館（NLM）

Basiliximab Induction: A Strategy to Avoid Steroids in Renal Transplant Recipients

Organ transplantation is a life-saving procedure, but it often requires a complex regimen of immunosuppressive medications to prevent rejection. This multicenter, randomized study explores the potential of basiliximab induction to reduce the need for steroids in renal transplant recipients. The study aims to identify a safer and more effective approach to immunosuppression, much like a desert traveler seeking a more efficient and sustainable route through a challenging landscape.

Evaluating the Effectiveness of Basiliximab Induction in Renal Transplant

The authors demonstrate that basiliximab induction significantly reduces the need for additional immunosuppression, including steroids, in renal transplant recipients. This finding suggests that basiliximab may be a valuable strategy for avoiding the potential side effects of steroids.

Improving Outcomes for Renal Transplant Recipients

This research highlights the potential for improving outcomes for renal transplant recipients through targeted and individualized immunosuppression. It's like a camel caravan adapting to the changing conditions of the desert: understanding the specific needs of each member of the caravan and tailoring the journey accordingly.

Dr.Camel's Conclusion

This study is a significant contribution to the field of renal transplantation. It shows that basiliximab induction can effectively reduce the need for steroids, potentially leading to better long-term outcomes for transplant recipients. It's like finding a hidden oasis: a source of hope and a potential solution to a challenging problem.

Date :
  1. Date Completed 2005-03-22
  2. Date Revised 2019-07-13
Further Info :

Pubmed ID

15699766

DOI: Digital Object Identifier

10.1097/01.tp.0000151006.86197.76

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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