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Weight loss-associated changes in acute effects of nateglinide on insulin secretion after glucose loading: results of glucose loading on 2 consecutive days.

Author: MamoriS, MoriY, TajimaN

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Weight loss in obese patients with polycystic ovary syndrome (PCOS) was associated with improved insulin response to nateglinide, likely due to reduced visceral fat and improved early insulin response.
Paper Details　
Original Abstract of the Article :
AIM: The aim of this study was to investigate the influence of changes in insulin resistance and early insulin secretion on the insulin secretagogic effects of nateglinide. METHODS: Oral glucose tolerance testing (OGTT, 75 g) was performed in obese patients before and after weight loss on 2 consecu...See full text at original site
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引用元：
https://doi.org/10.1111/j.1463-1326.2004.00384.x

データ提供：米国国立医学図書館（NLM）

The Influence of Weight Loss on Nateglinide's Effects on Insulin Secretion

This research explores the intriguing connection between weight loss and the insulin-secretagogic effects of nateglinide. It's like embarking on a journey through a desert landscape, where the effects of weight loss on glucose metabolism are revealed. The researchers found that weight loss, accompanied by improvements in insulin resistance and early insulin secretion, significantly enhanced the insulin-stimulating effects of nateglinide.

Weight Loss Amplifies Nateglinide's Insulin-Stimulating Effect

The study demonstrates a significant increase in DeltaI30/DeltaG30, a measure of early insulin response, after weight loss. This finding suggests that weight loss can potentiate the beneficial effects of nateglinide in improving glucose control. It's like discovering a hidden oasis of improved metabolic function, where weight loss unlocks a more efficient way to regulate blood sugar levels.

Weight Loss: A Pathway to Enhanced Insulin Sensitivity

The study highlights the significant role of weight loss in improving insulin sensitivity and enhancing the effectiveness of medications like nateglinide. It's like paving a new path through the desert of metabolic dysfunction, where weight loss leads to a more efficient and balanced glucose metabolism. This research encourages us to recognize the powerful impact of weight loss on improving insulin sensitivity and optimizing glucose control.

Dr. Camel's Conclusion

This research reveals the fascinating interplay between weight loss and the effectiveness of nateglinide. It's like discovering a hidden oasis of improved metabolic function, where weight loss unlocks a more efficient way to regulate blood sugar levels. This research encourages us to recognize the powerful impact of weight loss on improving insulin sensitivity and optimizing glucose control.

Date :
  1. Date Completed 2005-06-09
  2. Date Revised 2018-12-17
Further Info :

Pubmed ID

15715891

DOI: Digital Object Identifier

10.1111/j.1463-1326.2004.00384.x

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SNS
PICO Info
in preparation
Languages

English

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