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Theophylline-induced behavior change in children. An objective evaluation of parents' perceptions.

Author: BenderB, MilgromH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Parental beliefs about theophylline-induced behavioral side effects were not supported by their own observations.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate children who take theophylline for the presence of behavioral side effects and to determine whether the beliefs about these side effects held by their parents are supported by their own observations. DESIGN: A double-blind, placebo-controlled, randomized, crossover protocol. ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1573749

データ提供：米国国立医学図書館（NLM）

Theophylline and Behavior: Navigating the Desert of Side Effects

Theophylline, a medication commonly used to treat asthma, has been associated with behavioral side effects in children. This study, published in Pediatrics, aimed to objectively evaluate the perceptions of parents who reported observing these side effects in their children. The researchers conducted a double-blind, placebo-controlled, randomized, crossover trial to determine whether theophylline actually caused the observed behavioral changes.

Theophylline: Separating Fact from Fiction

The study found no significant differences in the children's behavior when they were taking theophylline compared to placebo, despite parental reports of behavioral problems. While the children did exhibit some minor changes in attention and anxiety, these changes were small and not consistently linked to theophylline levels. It's like navigating a desert mirage, where what appears to be a shimmering oasis turns out to be an illusion. This study suggests that parental perceptions of theophylline's effects may not always align with objective measures.

Theophylline: A Cautionary Tale

This study highlights the importance of considering both parental reports and objective evidence when evaluating the effects of medications. It's a reminder that the body's response to medication can be complex and variable, and sometimes what appears to be a side effect may be due to other factors. Just as a camel must learn to discern real water sources from mirages in the desert, we must learn to distinguish between real and perceived effects of medications.

Dr.Camel's Conclusion

This study challenges the common perception of theophylline-induced behavioral changes in children. It underscores the need for careful assessment of medications and their effects, considering both parental reports and objective evidence. Remember, the journey of medical research is a continuous exploration, and new discoveries often challenge our preconceived notions.

Date :
  1. Date Completed 1992-06-02
  2. Date Revised 2016-10-17
Further Info :

Pubmed ID

1573749

DOI: Digital Object Identifier

1573749

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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