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Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.

Author: ChenXiaoxin, FangMingzhu, LiNing, SoodSandeep, SunZheng, WangPeng, WangSu, YangChung S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study aims to evaluate the contribution of the 5-lipoxygenase (5-Lox) pathway to oral carcinogenesis and the potential synergistic or additive effects of combining inhibitors of both the cyclooxygenase (Cox) and 5-Lox pathways.
Paper Details　
Original Abstract of the Article :
Previous studies have suggested an important role of aberrant arachidonic acid metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis. However, it is unknown whether the 5-lipoxygenase (5-Lox) pathway contributes to oral carcinogenesis, and whether combination of inhibitors ...See full text at original site
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引用元：
https://doi.org/10.1158/1078-0432.CCR-04-1684

データ提供：米国国立医学図書館（NLM）

Oral Cancer: A Battle on Two Fronts

This study delves into the complex world of oral cancer, exploring the role of aberrant arachidonic acid metabolism in its development. The researchers investigated the expression of 5-lipoxygenase (5-LOX) and cyclooxygenase 2 (COX-2), two enzymes involved in arachidonic acid metabolism, in both hamster and human oral cancer cells. They discovered that both enzymes were overexpressed in these cancerous cells, suggesting their potential role in the development of oral cancer. The study further explored the chemopreventive effects of zileuton and celecoxib, inhibitors of 5-LOX and COX-2, respectively. The findings suggest that these inhibitors could potentially prevent or delay the development of oral cancer.

A Two-Pronged Approach to Oral Cancer Prevention

The study reveals the potential of a two-pronged approach to preventing oral cancer, targeting both the 5-LOX and COX-2 pathways. Imagine a camel caravan navigating a desert - a well-planned route that avoids both sandstorms and treacherous cliffs is essential for a successful journey. Similarly, targeting multiple pathways involved in oral cancer development could potentially increase the chances of successful prevention.

A Beacon of Hope for Oral Cancer Prevention

This study offers hope for preventing oral cancer. While further research is needed to confirm the effectiveness of these inhibitors in human patients, it suggests a potential avenue for developing new preventive strategies. It's like a camel finding a hidden oasis in the desert - a promising discovery that could lead to a more effective and hopeful journey towards cancer prevention.

Dr.Camel's Conclusion

This study investigates the potential of targeting both 5-LOX and COX-2 pathways to prevent oral cancer. It highlights the importance of exploring multiple pathways involved in cancer development to create more effective preventive strategies.

Date :
  1. Date Completed 2005-06-20
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

15756036

DOI: Digital Object Identifier

10.1158/1078-0432.CCR-04-1684

Related Literature

Article Analysis
・Effects of zileuton
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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