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Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine.

Author: Aparicio PagesM Nieves, DerijksLuc J J, MulderChris J J, de BoerNanne K H, de BoerSybrand Y, van NieuwkerkCarin M J

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study reports three patients with autoimmune hepatitis who could not tolerate azathioprine but tolerated 6-thioguanine 0.3 milligram per kilogram daily well. All three patients improved clinically.
Paper Details　
Original Abstract of the Article :
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted. Azathioprine, a purine analogue, is frequently used to taper or replace corticosteroids. However, appro...See full text at original site
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引用元：
https://doi.org/10.1097/00042737-200504000-00012

データ提供：米国国立医学図書館（NLM）

A New Path for Autoimmune Hepatitis: Navigating Treatment Options

Autoimmune hepatitis is a serious liver disease that occurs when the body’s immune system attacks its own liver cells. The treatment of autoimmune hepatitis typically involves corticosteroids, which are powerful drugs that can have significant side effects. This study explored the use of 6-thioguanine, a drug that suppresses the immune system, as an alternative to corticosteroids in patients with autoimmune hepatitis who could not tolerate azathioprine, another immunosuppressant. The researchers found that 6-thioguanine was well tolerated and effective in treating autoimmune hepatitis in these patients.

6-Thioguanine: A New Oasis for Autoimmune Hepatitis

This study suggests that 6-thioguanine might be a viable treatment option for autoimmune hepatitis in patients who are intolerant to azathioprine. It’s like finding a hidden oasis in the desert of autoimmune hepatitis treatments, offering a new path for patients who need alternative therapies.

Managing Autoimmune Hepatitis: Seeking the Right Treatment

Autoimmune hepatitis is a complex condition, and treatment options vary depending on the individual case. It’s essential to talk to a doctor about the best course of treatment for you.

Dr.Camel's Conclusion

This research highlights the importance of finding personalized treatments for autoimmune hepatitis. 6-thioguanine offers a promising alternative for patients who cannot tolerate azathioprine. Remember, working closely with your doctor is crucial to finding the right treatment and achieving optimal outcomes.

Date :
  1. Date Completed 2005-05-31
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

15756101

DOI: Digital Object Identifier

10.1097/00042737-200504000-00012

Related Literature

Article Analysis
・Side Effects of thioguanine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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