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Effects of itraconazole or grapefruit juice on the pharmacokinetics of telithromycin.

Author: BhargavaVijay O, LeroyBruno, MontayGuy, ShiJun

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Coadministration of the cytochrome P450 3A4 (CYP3A4) inhibitor itraconazole with telithromycin increased the steady-state area under the plasma concentration-time curve from 0-24 hours of telithromycin by 53.8%. Coadministration of grapefruit juice did not affect telithromycin pharmacokinetic parameters.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVE: To determine whether coadministration of the cytochrome P450 3A4 (CYP3A4) inhibitors itraconazole or grapefruit juice will modify the pharmacokinetic profile of telithromycin, and to assess the safety of telithromycin. DESIGN: Two single-center, open-label studies; the itraconazole...See full text at original site
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引用元：
https://doi.org/10.1592/phco.25.1.42.55621

データ提供：米国国立医学図書館（NLM）

Effect of Itraconazole and Grapefruit Juice on Telithromycin Pharmacokinetics

Telithromycin is an antibiotic used to treat bacterial infections. Itraconazole and grapefruit juice are known to inhibit the CYP3A4 enzyme, which is involved in the metabolism of telithromycin. This study investigated the effects of co-administering itraconazole or grapefruit juice with telithromycin on its pharmacokinetic profile and safety. The study found that itraconazole significantly increased the plasma concentration of telithromycin, while grapefruit juice had no significant effect. Telithromycin was well-tolerated in both studies.

Itraconazole Interaction with Telithromycin

This study highlights the importance of considering potential drug interactions. Co-administering itraconazole with telithromycin can lead to increased telithromycin levels in the body, which could increase the risk of adverse effects. This finding underscores the need for careful monitoring when these medications are used together.

Dr.Camel's Perspective on Drug Interactions

Imagine two travelers sharing a camel in the desert. One traveler (itraconazole) might make the camel (telithromycin) work harder, leading to a stronger effect, while the other traveler (grapefruit juice) might not have a noticeable impact. This study shows that drug interactions, like different travelers using the same camel, can have surprising effects. It's important to be aware of these interactions to ensure safe and effective treatment.

Dr.Camel's Conclusion

This research underscores the importance of understanding drug interactions, especially when it comes to medications that affect the CYP3A4 enzyme. Just like a camel navigating a complex desert landscape, healthcare providers must be aware of potential drug interactions to ensure patient safety and optimize treatment outcomes.

Date :
  1. Date Completed 2005-08-19
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

15767219

DOI: Digital Object Identifier

10.1592/phco.25.1.42.55621

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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