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Testicular uptake and radiation dose in patients receiving Zevalin and Pretarget CC49Fusion protein.

Author: BreitzHazel, BrezovichIvan, DuanJun, ForeroAndres, KhazaeliM B, LoBuglioAlbert, MeredithRuby, ShenSui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Testicular doses from Zevalin were found to be much lower than originally reported, and the median testicular dose from Pretarget CC49Fusion protein was less than half that of Zevalin.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Radiation dose to the testes from radionuclide therapies is of concern. This study evaluated image-quantification methods for testicular uptake in a phantom and in patients. METHODS: A 50-mL vial and a large water tank were used to simulate testes and the body, respectively. Activity con...See full text at original site
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引用元：
https://doi.org/10.1089/cbr.2005.20.110

データ提供：米国国立医学図書館（NLM）

Radiation Dose to the Testes During Radionuclide Therapies

This study delves into the realm of cancer treatment, focusing on the potential impact of radionuclide therapies, like Zevalin and Pretarget CC49Fusion protein, on the testes. The researchers investigated the testicular uptake and radiation dose from these therapies, seeking to understand the risks and optimize treatment strategies. This research aims to ensure the safety and effectiveness of these treatments, minimizing potential harm to reproductive health.

Quantifying Radiation Dose to the Testes

The study developed and validated methods for accurately quantifying the testicular uptake and radiation dose from Zevalin and Pretarget CC49Fusion protein therapies. The findings provide valuable insights into the potential risks to testicular tissue and help inform clinical decision-making.

Protecting Reproductive Health

This research highlights the importance of carefully evaluating and mitigating potential risks to reproductive health during cancer treatment. By understanding the radiation dose to the testes from different therapies, clinicians can make more informed decisions about treatment strategies, minimizing the potential for long-term complications.

Dr.Camel's Conclusion

Just as the desert sun can be both nurturing and scorching, radionuclide therapies, while powerful tools in cancer treatment, can also pose risks. This study serves as a reminder of the need for careful consideration of potential side effects and meticulous monitoring of patients undergoing these therapies, ensuring that the benefits of treatment outweigh the risks.

Date :
  1. Date Completed 2005-08-04
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

15778590

DOI: Digital Object Identifier

10.1089/cbr.2005.20.110

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