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Early intensification followed by allo-BMT or auto-BMT or a second intensification in adult ALL: a randomized multicenter study.

Author: AlessandrinoE P, BacigalupoA, BernasconiC, CarellaA M, FicarraF, LazzarinoM, LocatelliF, MorraE, PagnuccoG, ResegottiL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 96 patients with acute lymphoblastic leukemia (ALL) compared allogeneic bone marrow transplant (BMT), autologous bone marrow transplant (ABMT), and prolonged intensive chemotherapy (ICC) for treating minimal residual disease after remission. While a high number of early relapses occurred after intensive chemotherapy, suggesting it may not be the best approach, allogeneic BMT showed the best results (although not statistically significant). ABMT and ICC had similar outcomes, with some patients experiencing relapses later. The study recommends considering allogeneic BMT as soon as possible after achieving remission for high-risk ALL patients.
Paper Details　
Original Abstract of the Article :
In January 1987 we started a multicenter study in order to evaluate in adult ALL patients the results of an intensive chemotherapy effected early after CR, and to compare the efficacy of allogeneic BMT vs autologous BMT vs prolonged intensive chemotherapy in the attempt to eradicate minimal residual...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1578935

データ提供：米国国立医学図書館（NLM）

Early Intensification for Adult ALL: A Multifaceted Approach

This research examines the effectiveness of early intensification chemotherapy followed by different consolidation strategies in adult acute lymphoblastic leukemia (ALL). The study, employing a multicenter randomized design, compared the outcomes of allogeneic bone marrow transplantation (allo-BMT), autologous bone marrow transplantation (auto-BMT), and a second intensification chemotherapy regimen. The researchers meticulously analyzed disease-free survival (DFS) and relapse rates. Their findings highlight the complexities of managing adult ALL, emphasizing the need for personalized treatment strategies to optimize outcomes.

A Multifaceted Approach to Adult ALL Treatment

The study observed a high number of early relapses despite early intensification chemotherapy, suggesting that aggressive early treatment might not always be sufficient to eradicate minimal residual disease. The researchers found that allo-BMT demonstrated the best results in terms of DFS, although the differences between the treatment arms were not statistically significant. They concluded that allo-BMT should be considered as a primary consolidation strategy in high-risk patients, while auto-BMT and prolonged intensification might be suitable alternatives for other patients.

Navigating the Labyrinth of ALL Treatment

This research provides valuable insights into the complexities of managing adult ALL. The study's findings underscore the importance of personalized treatment strategies, taking into account individual patient factors such as risk status and availability of suitable donors. It’s like navigating a labyrinth of treatment options, carefully choosing the right path for each patient’s journey.

Dr. Camel's Conclusion

This study highlights the ongoing challenges of managing adult ALL, emphasizing the need for tailored treatment strategies to optimize outcomes. The findings suggest that allo-BMT might be the most effective consolidation strategy for high-risk patients, while auto-BMT and prolonged intensification could offer valuable alternatives. It's like finding a clear path through a vast and complex desert of ALL treatment options.
Date :
  1. Date Completed 1992-06-11
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

1578935

DOI: Digital Object Identifier

1578935

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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