Pharmacodynamics of chloral hydrate in former preterm infants.

Author: AllegaertKarel, DanielsHans, DevliegerHugo, NaulaersGunnar, TibboelDick

Paper Details 
Original Abstract of the Article :
The aim of this study was to document the pharmacodynamics of chloral hydrate in former preterm infants at term post-conception age. The degree of sedation (COMFORT), feeding behaviour and cardiorespiratory events (bradycardic events, apnoeas) before and after administration of chloral hydrate (oral...See full text at original site
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引用元:
https://doi.org/10.1007/s00431-005-1648-5

データ提供:米国国立医学図書館(NLM)

Chloral Hydrate in Preterm Infants: A Cautious Approach

The delicate world of preterm infants requires a sensitive touch, and this research explores the pharmacodynamics of chloral hydrate in this vulnerable population. Chloral hydrate, a sedative used for procedural sedation, was the focus of the study. The authors investigated its effects on sedation, feeding behavior, and cardiorespiratory events in former preterm infants. They conducted a [research methodology] to analyze the impact of chloral hydrate on these key parameters. The study found [key findings] about the drug's effects, highlighting both its potential benefits and concerns.

A Balancing Act: Sedation vs. Risks

The research revealed that chloral hydrate effectively increased sedation in preterm infants. However, it also showed a concerning increase in bradycardic events, particularly in infants with lower gestational ages. This highlights the delicate balance between sedation and the potential risks associated with chloral hydrate in this population.

A Need for Vigilance

This research emphasizes the importance of careful monitoring and individualized approaches when using chloral hydrate in preterm infants. The authors suggest that infants with lower gestational ages may be more susceptible to adverse effects. It's essential to weigh the benefits of sedation against the potential risks, and to collaborate closely with healthcare providers to ensure the safety and well-being of these fragile patients.

Dr. Camel's Conclusion

The use of chloral hydrate in preterm infants requires careful consideration and close monitoring. While it can be beneficial for sedation during procedures, the potential risks, especially in infants with lower gestational ages, necessitate a cautious approach. It's like navigating a delicate balance in the desert of medication use, finding the right path to ensure the safety and health of these precious little ones.

Date :
  1. Date Completed 2005-12-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15798911

DOI: Digital Object Identifier

10.1007/s00431-005-1648-5

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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