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Resistance to excessive bodyweight gain in risperidone-injected rats.
Author: KanekoYoko S, MoriKeiji, NakashimaAkira, OtaAkira, OtaMiyuki, TakahashiHisahide
Original Abstract of the Article :
1. The present study was carried out to explain the resistance of rats injected subcutaneously with risperidone, the atypical antipsychotic drug, for 21 consecutive days at 0.1 mg/kg per day (a dose equivalent to the one used for patients) to result in an excessive bodyweight despite the increase in...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/j.1440-1681.2005.04184.x
データ提供:米国国立医学図書館(NLM)
Risperidone: A Desert Oasis or a Shimmering Mirage?
The search for effective treatments for various conditions can feel like a journey through a vast and sometimes treacherous desert. This study delves into the potential benefits and risks of risperidone, an atypical antipsychotic drug, investigating its effects on body weight in rats. The researchers, exploring the complex relationship between risperidone and metabolism, found that despite risperidone's tendency to cause hypothermia and increase food intake, it did not lead to excessive weight gain in rats. They attributed this resistance to risperidone's effect on thermogenesis and lipid metabolism.
Unraveling the Desert's Secrets: Understanding Risperidone's Metabolic Effects
The study provides valuable insights into the metabolic effects of risperidone, suggesting that it might promote thermogenesis (heat production) and alter lipid metabolism, potentially contributing to the observed resistance to weight gain. This discovery could have significant implications for understanding the metabolic side effects of risperidone in humans.
Navigating the Desert of Weight Management: Balancing the Oasis and the Mirage
While the study provides intriguing information about risperidone's potential metabolic effects, it's important to remember that animal studies do not always translate directly to humans. Further research is needed to understand the implications of these findings for human health. Navigating the desert of weight management often involves finding a balance between potential benefits and risks, considering individual needs and circumstances.
Dr.Camel's Conclusion
This study offers a glimpse into the complex interplay between risperidone, metabolism, and weight management. It highlights the importance of understanding drug effects on various physiological processes, especially in the context of metabolic health. While the findings are promising, further research is crucial to confirm their applicability to humans and guide clinical practice.
Date :
- Date Completed 2005-09-12
- Date Revised 2013-11-21
Further Info :
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