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Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial.

Author: BassaAntoni, CifuentesCarmen, ConteAntonio, Costa-BauzáAntonia, FernándezCristina, GallegosCarmen, García-GonzálezRamón, GrasesFelix, HomarFrancisco, MartinezAna-Isabel, MurilloJosé A, PayerasAntoni, RedondoEnrique, RieraMelchor, SaroDulce, SartiniRaquel P, SimonetBartolomé M

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Indinavir, a protease inhibitor used to treat HIV-1 infection, can crystallize in the renal tubules, causing flank pain or renal colic. An in vitro study showed that adding escin to synthetic urine containing indinavir delayed the crystallization time.
Paper Details　
Original Abstract of the Article :
The combination of indinavir, a protease inhibitor, and reverse-transcriptase inhibitors is widely used in the treatment of HIV-1 infection. However, precipitation of indinavir crystals in the renal tubular lumen due to the drug's aqueous insolubility may result in characteristic symptoms of flank p...See full text at original site
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引用元：
https://doi.org/10.1016/j.clinthera.2004.12.014

データ提供：米国国立医学図書館（NLM）

Addressing Indinavir Crystallization in HIV-Infected Patients

This study explores a critical challenge in [HIV treatment] – the management of indinavir crystallization in the urine of patients with HIV-1 infection. The study utilizes a [multicenter, randomized, open-label, controlled, four-period crossover] design to investigate the effects of escin, a natural compound, on the crystallization time of indinavir in urine. The authors found that escin significantly delayed the crystallization time of indinavir, suggesting that it could potentially mitigate the risk of indinavir-induced renal complications.

Escin Shows Promise for Preventing Indinavir Crystallization

The findings highlight escin as a potential approach to manage indinavir crystallization in HIV-infected patients. This research underscores the importance of developing strategies to minimize drug-induced adverse effects and improve patient outcomes.

Managing HIV Treatment: A Balancing Act

This study emphasizes the need for careful management of HIV treatment, particularly in terms of minimizing drug-induced complications. Understanding the potential side effects of medications and exploring strategies to mitigate these effects is crucial for improving patient well-being. Just like a camel navigates the desert, managing HIV treatment requires a delicate balance.

Dr.Camel's Conclusion

This study explores the use of escin to delay indinavir crystallization in HIV-infected patients. It highlights the importance of minimizing drug-induced adverse effects and underscores the need for continued research to develop innovative solutions for improving patient outcomes.

Date :
  1. Date Completed 2005-04-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15823768

DOI: Digital Object Identifier

10.1016/j.clinthera.2004.12.014

Related Literature

Article Analysis
・Effects of indinavir
SNS
PICO Info
in preparation
Languages

English

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