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Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus.

Author: Mohamed-AliVidya, PinkneyJonathan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Insulin-like growth factor-1 (IGF-1) and its receptors are closely related to insulin and insulin receptors. While IGF-1 primarily regulates growth, insulin regulates fuel metabolism. However, these systems interact, and in diabetes, IGF-1 levels are often disturbed. Recombinant human IGF-1 (rhIGF-1) has shown promise in improving insulin sensitivity and glycemic control in short-term studies of type 1 and 2 diabetes. However, further research is needed to assess the long-term benefits and risks of IGF-1 therapy.
Paper Details　
Original Abstract of the Article :
Insulin-like growth factor-1 (IGF-1) and its receptors share considerable homology with insulin and insulin receptors, and their respective signaling pathways interact at the post receptor level. While the growth hormone (GH)-IGF-1 axis principally regulates tissue growth and differentiation, insuli...See full text at original site
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引用元：
https://doi.org/10.2165/00024677-200201060-00005

データ提供：米国国立医学図書館（NLM）

IGF-1: A Potential Ally in the Battle Against Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by high blood sugar levels. Insulin-like growth factor-1 (IGF-1) plays a crucial role in regulating tissue growth and development. However, in diabetes mellitus, the GH-IGF-1 axis is disrupted, leading to reduced IGF-1 levels and potentially contributing to the development of insulin resistance. This study explores the potential of using recombinant human IGF-1 (rhIGF-1) to improve insulin sensitivity and glycemic control in patients with diabetes.

Potential Benefits of rhIGF-1 in Diabetes

Studies have shown that rhIGF-1 can significantly improve insulin sensitivity, reduce insulin requirements, and improve glycemic control in patients with type 1 and type 2 diabetes. Imagine a desert caravan struggling to find water. rhIGF-1, like a well-equipped scout, can identify and locate precious water sources, making it easier for the caravan to survive and thrive. Similarly, rhIGF-1 can help the body utilize insulin more effectively, ensuring that the cells receive the energy they need to function properly.

rhIGF-1: A Potential Tool for Combating Insulin Resistance

While rhIGF-1 holds promise as a treatment for diabetes, further research is needed to understand its long-term effects and to determine its optimal use in clinical practice.

Dr.Camel's Conclusion

This study highlights the potential of rhIGF-1 as a therapeutic agent for diabetes. However, further investigation is essential to optimize its use and understand its long-term effects. The journey to combat diabetes is a long and challenging one, and rhIGF-1 may offer a promising tool in the fight against this complex disease.

Date :
  1. Date Completed 2005-05-18
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

15832492

DOI: Digital Object Identifier

10.2165/00024677-200201060-00005

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