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Probing for affective side effects of drugs used in geriatric practice: use of daily diaries to test for effects of metoclopramide and naproxen.

Author: DattoCatherine, DiFilippoSuzanne, HaveThomas Ten, KatzIra R, MoralesKnashawn, OslinDavid, StreimJoel

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study explored the use of daily diaries to assess the affective toxicity of metoclopramide and naproxen in elderly patients. Both drugs were found to influence the relationship between daily events and affect.
Paper Details　
Original Abstract of the Article :
The aim of this study was to develop the use of daily diaries of affects and events as measures of pharmacological effects on affective processes and to apply them to evaluate the possible affective toxicity of metoclopramide and naproxen, two medications commonly used in geriatric practice. In all,...See full text at original site
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引用元：
https://doi.org/10.1038/sj.npp.1300751

データ提供：米国国立医学図書館（NLM）

Metoclopramide and Naproxen: Mood Effects in Older Adults

As we age, we navigate a vast desert of life experiences, sometimes encountering the effects of medications differently. This study, like a caravan of scientists, investigated the potential mood effects of metoclopramide and naproxen, two medications commonly used in geriatric practice. The researchers used daily diaries to track the mood and affect of 105 older adults who were randomly assigned to receive metoclopramide, naproxen, or a placebo.

Mixed Results: Navigating the Desert of Mood

The study found that while neither metoclopramide nor naproxen significantly affected mood or affect on their own, they did seem to influence how individuals responded to daily events. Metoclopramide amplified the impact of negative events on both positive and negative affect, while naproxen amplified the impact of positive events on positive affect. This suggests that these medications may not directly alter mood but can influence how individuals experience and process emotional experiences.

Navigating the Desert of Aging

This study, like a seasoned traveler, acknowledges the complexity of aging and the importance of understanding how medications might affect individuals differently. While the study does not suggest that these medications directly cause mood problems, it does suggest that they may influence how individuals respond to daily events. This knowledge is valuable for healthcare providers who work with older adults, enabling them to personalize medication regimens and support patients through the challenges of aging.

Dr.Camel's Conclusion

This research, like a caravan navigating the vast desert of aging, offers a valuable reminder of the importance of personalized medicine. The study suggests that metoclopramide and naproxen, while generally safe, may influence how individuals respond to daily events. This highlights the importance of individualized care and open communication between patients and healthcare providers when managing medications.
Date :
  1. Date Completed 2005-11-29
  2. Date Revised 2015-03-11
Further Info :

Pubmed ID

15856076

DOI: Digital Object Identifier

10.1038/sj.npp.1300751

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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