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Cholesterol-lowering effects of rosuvastatin compared with atorvastatin in patients with type 2 diabetes -- CORALL study.

Author: , FrankenA A M, VincentH H, WolffenbuttelB H R

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Rosuvastatin was more effective than atorvastatin in reducing apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio in patients with type 2 diabetes. Rosuvastatin also reduced LDL-C more effectively than atorvastatin and achieved the American Diabetes Association LDL-C goal in a greater percentage of patients.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To compare the efficacy of the newest cholesterol-lowering drug, rosuvastatin (RSV) with atorvastatin (ATV) in subjects with type 2 diabetes. DESIGN: A 24-week, open-label, randomized, parallel-group, phase IIIb, multicentre study. SETTING: Diabetes outpatient clinics of 26 hospitals i...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2796.2005.01499.x

データ提供：米国国立医学図書館（NLM）

Cholesterol-Lowering Effects of Rosuvastatin Compared with Atorvastatin in Patients with Type 2 Diabetes: CORALL Study

This randomized controlled trial delves into the world of cardiovascular health, specifically focusing on the management of cholesterol levels in individuals with type 2 diabetes. Imagine cholesterol as a layer of sand accumulating in a desert oasis, potentially blocking the flow of water and disrupting its balance. The researchers compared the effectiveness of two cholesterol-lowering medications, rosuvastatin and atorvastatin, in reducing cholesterol levels and improving cardiovascular health.

Rosuvastatin: A More Effective Cholesterol-Lowering Agent

The study revealed that rosuvastatin demonstrated greater improvements in lipid parameters, including a more significant reduction in apolipoprotein B/apolipoprotein A1 ratio, compared to atorvastatin. This finding suggests that rosuvastatin may be a more effective cholesterol-lowering agent, potentially leading to better cardiovascular outcomes. It's like discovering a more efficient sand removal system for the desert oasis, preventing the accumulation of sand and maintaining a steady flow of water.

Cardiovascular Health: Managing Cholesterol

This study emphasizes the importance of effective cholesterol management in individuals with type 2 diabetes. It highlights the potential for rosuvastatin to provide greater benefit in reducing lipid levels and improving cardiovascular health. It's like finding a new way to irrigate a desert oasis, ensuring a constant supply of water and promoting its overall health.

Dr.Camel's Conclusion

This research sheds light on the potential advantages of rosuvastatin over atorvastatin in managing cholesterol levels in individuals with type 2 diabetes. It underscores the importance of personalized medication choices and ongoing monitoring to optimize cardiovascular health. It's like understanding the unique needs of a desert oasis and adapting our irrigation strategies to ensure its survival and prosperity.
Date :
  1. Date Completed 2005-06-30
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15910557

DOI: Digital Object Identifier

10.1111/j.1365-2796.2005.01499.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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