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The efficacy and adverse effects of GPO-VIR (stavudine+lamivudine+nevirapine) in treatment-naïve adult HIV patients.

Author: BowonwatanuwongChureeratana, DesakornVarunee, KrudsoodSrivicha, PitisuttithumPunnee, TinEi Ei, WilairatanaPolrat

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study assessed the efficacy of GPO-VIR (stavudine, lamivudine, and nevirapine) for the treatment of HIV-treatment-naïve patients. The study found that GPO-VIR is an inexpensive and effective antiretroviral drug regimen for initiating treatment of naïve patients. After 12 months of treatment, 52.3% of patients had a body weight increase >10% of pre-treatment body weight. CD4 T-cell counts increased rapidly after treatment, and the occurrence of opportunistic infections was significantly lower. However, 16.8% of patients developed lipodystrophy within 2 years of treatment. This suggests that GPO-VIR is an effective treatment but that careful monitoring for lipodystrophy is necessary.
Paper Details　
Original Abstract of the Article :
A descriptive, combined retrospective and prospective study was conducted at the Anonymous Clinic, Chon Buri Hospital, Chon Buri Province, Thailand from November 10, 2003 to January 4, 2004. A total of 83 adult HIV-treatment-naïve patients undergoing treatment with GPO-VIR (stavudine, lamivudine, an...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15916042

データ提供：米国国立医学図書館（NLM）

GPO-VIR: A Beacon of Hope in the Desert of HIV Treatment

The [fight against HIV] is a relentless journey through the [desert of a complex disease]. This study delves into the [efficacy and side effects] of [GPO-VIR, a combination antiretroviral drug regimen] for [treatment-naive adult HIV patients]. The authors found that [GPO-VIR is an inexpensive and effective treatment] that leads to [significant improvements] in [CD4 T-cell counts] and [reduced occurrence of opportunistic infections]. However, they also highlight the [potential for lipodystrophy], a [side effect] that requires [careful monitoring].

GPO-VIR: A Promising Treatment for HIV

This study highlights the [potential of GPO-VIR] as a [cost-effective and effective] treatment for [HIV]. The data suggests that [GPO-VIR] can lead to [significant improvements] in [patient health] and [quality of life].

Navigating the Desert of HIV: Considerations for Patients

Patients with [HIV] should [discuss the potential risks and benefits] of [GPO-VIR] with their doctor. [Open communication and regular monitoring] are essential for [effective management] of this complex condition.

Dr.Camel's Conclusion

The desert of HIV is a harsh and unforgiving environment. This study offers a ray of hope in the form of GPO-VIR, an [effective and affordable] treatment option. We hope that ongoing research will lead to [even better treatments] and [a brighter future] for those living with HIV.

Date :
  1. Date Completed 2005-06-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15916042

DOI: Digital Object Identifier

15916042

Related Literature

Article Analysis
・Effects of stavudine・Effects of nevirapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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