Paper Details

  1. Home
  2. Paper Details

Purine nucleosides stimulate Na/K ATPase, and prolong survival in hemorrhagic shock.

Author: DarlingtonDaniel N, GannDonald S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study searched for adenosine analogs that stimulate Na/K ATPase activity without the side effect of bradycardia. Adenosine is known to stimulate Na/K ATPase activity and lower plasma potassium, but it also causes bradycardia. The study aimed to identify analogs that could provide the beneficial effects of adenosine without the adverse effect of bradycardia.
Paper Details　
Original Abstract of the Article :
Hemorrhagic shock leads to the appearance of substances in plasma that depress Na/K ATPase activity leading to a rise in plasma potassium. Recently, we reported that adenosine can stimulate Na/K ATPase activity, lower the plasma potassium back to control and prolong survival in shocked rats. However...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/01.ta.0000169801.08019.b9

データ提供：米国国立医学図書館（NLM）

Hemorrhagic Shock: A Lifeline of Purine Nucleosides

This research investigates the potential of [purine nucleosides] in improving [survival] in [hemorrhagic shock]. The study explores the effects of [purine nucleosides] on [Na/K ATPase activity], a key enzyme involved in [cellular function], and their impact on [plasma potassium levels] in animals experiencing [hemorrhagic shock].

Purine Nucleosides: Restoring Balance in Shock

The study suggests that [purine nucleosides] can stimulate [Na/K ATPase activity], lowering [plasma potassium levels] and potentially prolonging [survival] in [hemorrhagic shock]. This research highlights the potential of [purine nucleosides] as a therapeutic agent for [hemorrhagic shock].

Emergency Medicine: Navigating Life-Threatening Situations

This study reinforces the importance of [early intervention] and [appropriate treatment] in managing [hemorrhagic shock]. It's essential to seek immediate medical attention for any signs of [shock] and trust in the expertise of [medical professionals] to provide the best possible care.

Dr. Camel's Conclusion

This research delves into the fascinating world of [purine nucleosides] and their potential to combat [hemorrhagic shock]. It's like discovering a hidden oasis in the desert, offering a lifeline of hope for those facing this life-threatening condition.

Date :
  1. Date Completed 2005-06-28
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15920424

DOI: Digital Object Identifier

10.1097/01.ta.0000169801.08019.b9

Related Literature

Article Analysis
・Side Effects of dipyridamole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.