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Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.

Author: AlomarAgustin, DalmauJoan, PeramiquelLaura, PimentelCarmen Lucia, PuigLuis, RoéEsther

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Overview

Pegylated interferon alfa-2b can cause local cutaneous reactions at sites of injection. These reactions can range from mild to severe and may require dose modification or treatment withdrawal.
Paper Details　
Original Abstract of the Article :
Pegylated interferon alfa-2b is a formulation of recombinant human interferon conjugated with polyethylene glycol. Compared with standard interferon alfa injections, this preparation has a longer half-life allowing for once-weekly injections and superior antiviral efficacy in the treatment of hepati...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaad.2005.02.031

データ提供：米国国立医学図書館（NLM）

Pegylated Interferon Alfa-2b: A Potential Oasis in the Treatment of Hepatitis C, but with a Few Thorns

Interferon alfa-2b, a key player in hepatitis C treatment, has been modified with polyethylene glycol (PEG) to create a longer-lasting version. This modification, like finding a lush oasis in a parched desert, has led to improvements in antiviral efficacy. However, like any oasis, this treatment comes with its share of thorns - in this case, the possibility of cutaneous side effects.

Navigating the Risks of Pegylated Interferon Alfa-2b

The study highlights a rare but concerning complication - cutaneous necrosis, or tissue death, occurring at injection sites. While the precise mechanism is unknown, this study investigates potential culprits, including local immune-mediated inflammatory processes.

A Desert of Uncertainties: Managing Cutaneous Reactions

The authors emphasize the importance of vigilance in monitoring for these side effects. They note that the ulcers typically heal with local therapy, but in some cases, dose adjustments or even treatment withdrawal may be necessary. Navigating the balance between treatment benefits and potential risks is crucial, and doctors must carefully weigh these factors when treating patients.

Dr.Camel's Conclusion

Just as a camel must navigate the desert with caution, doctors must carefully weigh the benefits and risks of using pegylated interferon alfa-2b. The study serves as a reminder that even seemingly miraculous treatments can have unforeseen side effects. Constant vigilance and careful monitoring are crucial for ensuring the safety and well-being of patients.

Date :
  1. Date Completed 2006-05-04
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15965422

DOI: Digital Object Identifier

10.1016/j.jaad.2005.02.031

SNS
PICO Info
in preparation
Languages

English

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