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Hemostatic effects of fibrinogen gamma-chain dodecapeptide-conjugated polymerized albumin particles in vitro and in vivo.

Author: HandaMakoto, IkedaYasuo, MaruyamaHitomi, OkamuraYosuke, TakeokaShinji, TeramuraYuji, TsuchidaEishun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

H12-polyAlb, a dodecapeptide conjugated to polymerized albumin particles, enhanced thrombus formation in vitro and demonstrated hemostatic effects in thrombocytopenic rats. This suggests that H12-polyAlb may be a suitable candidate for a platelet substitute.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Prototypes of platelet (PLT) substitutes have been studied and the focus was on a dodecapeptide, HHLGGAKQAGDV (H12), which is a fibrinogen gamma-chain carboxy-terminal sequence (gamma 400-411) and exists only in the fibrinogen domain. STUDY DESIGN AND METHODS: H12 was conjugated to the ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1537-2995.2005.00173.x

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2005-08-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15987370

DOI: Digital Object Identifier

10.1111/j.1537-2995.2005.00173.x

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