Prospective study of estramustine phosphate for hormone refractory prostate cancer patients following androgen deprivation therapy.

Author: EndohMakoto, HachiyaTakahiko, HiranoDaisaku, IshidaHajime, KishimotoYuichi, MineiSadatsugu, OkadaKiyoki, SatohYasuo, TakimotoYukie, YamaguchiKenya, YamamotoTadao, YamanakaYataroh, YoshidaToshio, YoshikawaTetsuo

Paper Details 
Original Abstract of the Article :
Estramustine phosphate (EMP) in combination with other cytotoxic agents has been widely used in clinical trials as an anti-tumor agent for the treatment of hormone-refractory prostate cancer (HRPC). However, few prospective studies have considered the efficacy of EMP monotherapy for HRPC patients fo...See full text at original site
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引用元:
https://doi.org/10.1159/000085926

データ提供:米国国立医学図書館(NLM)

Exploring Estramustine Phosphate for Prostate Cancer Treatment

The world of prostate cancer research is like a vast desert, filled with challenges. This research tackles a significant hurdle – finding effective treatments for hormone-refractory prostate cancer (HRPC). The study focuses on Estramustine Phosphate (EMP), a medication often combined with other anti-tumor agents. However, researchers wanted to see if EMP could stand alone in treating HRPC patients who have already gone through androgen deprivation therapy (ADT). They conducted a prospective study, which is like a desert expedition with a clear path, to observe the impact of EMP on PSA levels. The researchers found that EMP might be a viable option for these patients, with changes in PSA levels serving as a key indicator of effectiveness.

A Glimpse of Hope for Hormone-Refractory Prostate Cancer

This study suggests that EMP monotherapy could be a potential treatment option for HRPC patients who have already undergone ADT. The researchers used a prospective study design, which means they followed a group of patients over time to observe the effects of EMP on PSA levels. This careful approach provided valuable insights into the potential effectiveness of EMP as a solo treatment for HRPC. The researchers found that changes in PSA levels were a reliable marker for assessing the efficacy of EMP in this specific patient group. This discovery could lead to new treatment strategies for patients with HRPC who are not responding well to other treatments.

A Sandcastle of Hope in the Desert of Prostate Cancer

This research offers a ray of hope for patients battling HRPC. The study suggests that EMP monotherapy could be a promising treatment strategy, especially for patients who have already undergone ADT. It's important to note that while this study shows potential, more research is needed to confirm the long-term benefits and safety of EMP monotherapy. Think of it like building a sandcastle in the desert – it takes time, care, and patience to make it strong and stable. Similarly, we need to carefully evaluate the impact of EMP monotherapy to ensure its effectiveness and safety for patients with HRPC.

Dr. Camel's Conclusion

This research is a step forward in the quest for effective treatments for HRPC. The study suggests that EMP monotherapy could be a viable option for patients who have already undergone ADT. While more research is needed, this discovery holds promise for improving the lives of patients with this challenging condition. Think of it like a camel finding a cool oasis in the hot desert – a moment of relief and hope in a difficult journey.

Date :
  1. Date Completed 2005-11-08
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

16037707

DOI: Digital Object Identifier

10.1159/000085926

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SNS
PICO Info
in preparation
Languages

English

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