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Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons.

Author: ErhardtS, LinderholmK R, NilssonL K

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of subchronic exposure to kynurenine and probenecid, which increase brain kynurenic acid (KYNA) turnover, on rat ventral tegmental area (VTA) dopamine neurons and prepulse inhibition (PPI). The study found that this treatment increased neuronal firing of VTA DA neurons and disrupted PPI, suggesting that the effects of acutely elevated KYNA levels on VTA DA neurons persist following subchronic exposure.
Paper Details　
Original Abstract of the Article :
Acute elevation of the endogenous NMDA-receptor antagonist kynurenic acid (KYNA) is associated with an increased neuronal activity of rat ventral tegmental area (VTA) dopamine (DA) neurons and disruption in prepulse inhibition (PPI). In the present study, the effects of subchronic exposure to kynure...See full text at original site
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引用元：
https://doi.org/10.1007/s00702-005-0343-z

データ提供：米国国立医学図書館（NLM）

Kynurenine and Probenecid: Impact on Dopamine Neuron Firing and Prepulse Inhibition

The intricate workings of the brain are a fascinating subject, and understanding the interplay of neurochemicals is crucial for unraveling complex neurological processes. This study investigates the impact of kynurenine and probenecid, two substances that influence brain chemistry, on dopamine neuron firing and prepulse inhibition (PPI).

Kynurenine and Probenecid: Impact on Dopamine Neuron Firing and Prepulse Inhibition

The research found that subchronic treatment with kynurenine and probenecid increased the firing rate of dopamine neurons in the ventral tegmental area (VTA). It also disrupted PPI, a measure of sensorimotor gating. These findings suggest that kynurenine and probenecid can influence dopamine neuron activity and potentially contribute to neurological disorders associated with impaired sensorimotor gating.

Kynurenine and Probenecid: Impact on Dopamine Neuron Firing and Prepulse Inhibition

This study delves into the complex interplay of neurochemicals within the brain, providing valuable insights into the potential roles of kynurenine and probenecid in neurological function and dysfunction.

Dr.Camel's Conclusion

This research is like a journey through the intricate labyrinth of the brain. It highlights the important roles of kynurenine and probenecid in modulating dopamine neuron activity and potentially influencing neurological processes.
Date :
  1. Date Completed 2006-09-19
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

16082514

DOI: Digital Object Identifier

10.1007/s00702-005-0343-z

Related Literature

Article Analysis
・Effects of probenecid
SNS
PICO Info
in preparation
Languages

English

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