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Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites.

Author: BackmanJanne T, LuurilaHarri, NeuvonenMikko, NeuvonenPertti J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rifampin markedly decreases and gemfibrozil moderately increases the plasma concentrations of atorvastatin and its metabolites. It is advisable to increase the dosage of atorvastatin and preferable to administer it in the evening to guarantee adequate concentrations during the nighttime rapid cholesterol synthesis when rifampin or other potent inducers of cytochrome P450 3A4 are coadministered. Care is warranted, and only low doses of atorvastatin should be used if coadministration with gemfibrozil is needed.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The pharmacokinetic interactions of the widely used statin atorvastatin with fibrates and enzyme inducers are not known. Therefore we studied the effects of rifampin (INN, rifampicin) and gemfibrozil on the pharmacokinetics of atorvastatin. METHODS: Two randomized crossover studies were...See full text at original site
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引用元：
https://doi.org/10.1016/j.clpt.2005.04.007

データ提供：米国国立医学図書館（NLM）

Investigating the Pharmacokinetic Interactions of Atorvastatin with Rifampin and Gemfibrozil

This research explores the pharmacokinetic interactions between atorvastatin, a widely used statin, and two other medications: rifampin, an enzyme inducer, and gemfibrozil, a fibrate. The study used two randomized crossover designs to assess the effects of rifampin and gemfibrozil on the pharmacokinetic profile of atorvastatin and its metabolites. The findings revealed that rifampin significantly decreased the plasma concentrations of atorvastatin and its active metabolites, while gemfibrozil modestly increased these levels. The authors suggest that the dosage of atorvastatin may need to be adjusted when coadministered with rifampin or gemfibrozil.

Understanding the Importance of Pharmacokinetic Interactions in Medication Management

This research highlights the crucial importance of considering pharmacokinetic interactions when prescribing medications, particularly in patients taking multiple drugs. The study's findings demonstrate that rifampin, a potent enzyme inducer, can significantly reduce the effectiveness of atorvastatin, while gemfibrozil, a fibrate, can increase its levels in the body. These interactions underscore the need for careful medication management to ensure optimal therapeutic outcomes.

Navigating Drug Interactions: A Crucial Aspect of Medication Safety

This research emphasizes the importance of understanding and managing drug interactions to ensure patient safety and treatment efficacy. The study's findings illustrate the complex interplay between different medications and their potential to alter the pharmacokinetic profile of other drugs. Always consult with your physician to discuss potential drug interactions and to make informed decisions about your medication regimen.

Dr. Camel's Conclusion

This study reminds me of the intricate dance of molecules in the vast desert of our bodies. Just as different desert plants compete for scarce resources, medications can interact in unexpected ways, influencing each other's effectiveness. This research highlights the importance of mindful medication management to ensure that the therapeutic benefits of each drug are maximized while minimizing potential risks.
Date :
  1. Date Completed 2005-09-01
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

16084850

DOI: Digital Object Identifier

10.1016/j.clpt.2005.04.007

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Languages

English

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