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[The neuroprotective effects and its mechanisms of qingkailing injection on bacterial meningitis induced by E. coli in rabbits].

Author: DengShilin, FengDeyun, LiQiao-jun, LuoZi-qiang, TangFeige, YuPeilan, YueShao-jie

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Qingkailing injection (QKL) as an adjunctive treatment to antibiotics for E. coli-meningitis (CM) in rabbits reduced inflammatory reaction and brain injury. The mechanism may involve calcium antagonism and attenuation of MMP-9 expression.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To explore the neuro-protective effect and mechanism of qingkailing injection (QKL) against cerebral injury caused by E. coli-meningitis (CM). METHODS: The CM model rabbits were treated by ampicillin with QKL as adjuvant. The leukocyte count and protein content in cerebral spinal fluid (...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16089143

データ提供：米国国立医学図書館（NLM）

Neuroprotective Effects of Qingkailing Injection on Bacterial Meningitis in Rabbits

Bacterial meningitis, a serious infection of the brain and spinal cord, is like a sandstorm sweeping through a desert oasis, causing damage and disruption. This study examines the neuroprotective effects of qingkailing injection, a traditional Chinese medicine, against bacterial meningitis in rabbits. Imagine this injection as a protective shield against the sandstorm. The researchers used a rabbit model of E. coli-induced meningitis, a common type of bacterial meningitis. They found that qingkailing injection, when used as an adjunctive treatment alongside antibiotics, significantly reduced brain damage and inflammation. This effect was attributed to qingkailing's ability to reduce inflammation and protect brain cells from damage.

Promising Neuroprotection with Traditional Chinese Medicine

The research suggests that qingkailing injection, a traditional Chinese medicine, could play a valuable role in protecting the brain against bacterial meningitis, a serious infection. It's like a protective oasis within the raging sandstorm, shielding the brain from harm. Further research is needed to confirm its effectiveness in humans, but the study provides promising evidence for its potential benefits.

Dr. Camel's Conclusion

This research reminds us that traditional medicine holds valuable insights. Qingkailing injection, like a desert oasis offering respite from the harsh environment, might offer a path toward protecting the brain from bacterial meningitis.

Date :
  1. Date Completed 2005-11-25
  2. Date Revised 2016-10-18
Further Info :

Pubmed ID

16089143

DOI: Digital Object Identifier

16089143

SNS
PICO Info
in preparation
Languages

Chinese

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