Comparative pharmacokinetics and bioavailability study of percutaneous absorption of diclofenac from two topical formulations containing drug as a solution gel or as an emulsion gel.

Author: SethB L

Paper Details 
Original Abstract of the Article :
In a 3-way cross-over study on 12 healthy adult volunteers, the percutaneous absorption of diclofenac (CAS 15307-79-6) was studied for two topical formulations containing 1% diclofenac. The relative bioavailability from the test formulation (a solution gel) in terms of Cmax and AUC, calculated from ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/1610419

データ提供:米国国立医学図書館(NLM)

Diclofenac Delivery: Finding the Right Path through the Desert of Skin

Diclofenac, a common pain reliever, is often applied topically to target pain directly at the source. This research compares the percutaneous absorption of diclofenac from two different topical formulations: a solution gel and an emulsion gel. The study, like a skilled desert navigator, explores different routes for delivering this medication across the skin.

The Solution Gel: A Faster Path Through the Desert

The research finds that the solution gel formulation delivers diclofenac more efficiently into the bloodstream than the emulsion gel. The solution gel, like a well-trodden path through the desert, allows for faster and more effective delivery of the medication.

Navigating the Desert of Skin: A Personalized Approach

The study highlights the importance of choosing the right topical formulation for optimal diclofenac delivery. Just as a camel needs to select the best path through the desert, individuals using topical diclofenac should consider the specific needs of their skin and the desired therapeutic effect.

Dr.Camel's Conclusion

This research provides valuable insights into the percutaneous absorption of diclofenac from different topical formulations. The study emphasizes the importance of selecting the appropriate delivery system for optimal therapeutic efficacy. By understanding the intricacies of skin penetration, we can develop more effective and targeted methods for delivering medications to the skin, offering a more efficient and comfortable journey through the desert of pain management.

Date :
  1. Date Completed 1992-07-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1610419

DOI: Digital Object Identifier

1610419

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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