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The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis.

Author: BradleyJ D, BraterD C, HallS D, JonesD R, KrohnK, TracyT S

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

NSAIDs can affect the disposition of methotrexate, possibly increasing the potential for toxicity and necessitating dosage adjustments in patients with rheumatoid arthritis.
Paper Details　
Original Abstract of the Article :
We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all th...See full text at original site
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引用元：
https://doi.org/10.1007/BF00278469

データ提供：米国国立医学図書館（NLM）

The Intricate Dance of Drugs: Methotrexate and NSAIDs

Treating rheumatoid arthritis can feel like navigating a desert of pain and inflammation. This study explores the interaction between methotrexate, a common rheumatoid arthritis medication, and nonsteroidal anti-inflammatory drugs (NSAIDs). The researchers are studying the complex interplay of these drugs, much like investigating the delicate balance of a desert ecosystem.

The study found that NSAIDs can significantly impact the pharmacokinetics of methotrexate, potentially altering its effectiveness and increasing the risk of toxicity. It's like discovering that certain plants in the desert can have unexpected and even harmful effects on other species.

A Careful Dance: Managing Methotrexate and NSAIDs

This research sheds light on the delicate balance between methotrexate and NSAIDs. It's like learning to navigate a desert with a keen understanding of the unique properties of different plants. The study found that NSAIDs can significantly influence the body's handling of methotrexate, potentially increasing the risk of side effects.

The study emphasizes the importance of careful monitoring and dosage adjustments when using methotrexate and NSAIDs together. It's like navigating the desert with caution, respecting the intricate interplay between different elements of the ecosystem.

Dr.Camel's Conclusion

This research highlights the complex interaction between methotrexate and NSAIDs. It's like understanding the intricate dance of life in the desert, recognizing the subtle influences between different species. The findings underscore the importance of careful management and monitoring when using these drugs together to ensure patient safety and optimize treatment outcomes.

Date :
  1. Date Completed 1992-08-05
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

1618240

DOI: Digital Object Identifier

10.1007/BF00278469

Related Literature

Article Analysis
・Effects of choline magnesium trisalicylate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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