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Development of a sustained-release system for perivascular delivery of dipyridamole.

Author: BaeYou Han, CheungAlfred K, KernSteven E, MasakiTakahisa, RathiRamesh, ZhuWeiwei

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

A combination of PLGA microspheres and ReGel was developed for sustained perivascular delivery of dipyridamole, an antiproliferative drug, to prevent graft failure in dialysis patients.
Paper Details　
Original Abstract of the Article :
Vascular access grafts implanted in dialysis patients are prone to failure in the long-term because of stenosis and occlusion caused by neointimal hyperplasia. Local delivery of antiproliferative drugs may be effective to prevent this consequence while minimizing the systemic side effects they cause...See full text at original site
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引用元：
https://doi.org/10.1002/jbm.b.30412

データ提供：米国国立医学図書館（NLM）

Developing a Sustained-Release System for Perivascular Delivery of Dipyridamole

The field of [Vascular Surgery] is constantly seeking innovative strategies for improving the long-term outcomes of [vascular access grafts], which are essential for patients undergoing [dialysis]. This research explores the development of a [sustained-release system] for [perivascular delivery] of [dipyridamole], an [antiproliferative drug] that can help prevent [stenosis and occlusion] of these grafts. The study utilizes a [preclinical research] approach to develop and evaluate the efficacy of this novel delivery system, combining [poly(lactide-co-glycolide) (PLGA) microspheres] with [ReGel], an injectable copolymer.

A Novel Delivery System for Perivascular Drug Delivery

This preclinical research demonstrates the feasibility of developing a [sustained-release system] for [perivascular delivery] of [dipyridamole], an [antiproliferative drug] used to prevent [neointimal hyperplasia] in [vascular access grafts]. The study successfully developed a combination of [PLGA microspheres] and [ReGel] that effectively delivered [dipyridamole] for an extended period of time, reducing the initial burst release and achieving a more sustained release profile.

Improving the Longevity of Vascular Access Grafts

This research holds significant promise for improving the longevity of [vascular access grafts] and enhancing the quality of life for patients undergoing [dialysis]. The development of this [sustained-release system] for [perivascular delivery] of [dipyridamole] offers a potential solution to the challenges of [graft failure] due to [stenosis and occlusion]. It opens new avenues for optimizing [vascular access graft] management, extending their lifespan, and minimizing the need for repeated interventions.

Dr.Camel's Conclusion

Like a camel's journey across the desert, the success of vascular access grafts depends on their ability to sustain function over time. This research provides a roadmap for extending graft longevity by utilizing a novel sustained-release system for perivascular drug delivery, potentially reducing the need for interventions and improving the lives of dialysis patients.

Date :
  1. Date Completed 2006-09-05
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

16206204

DOI: Digital Object Identifier

10.1002/jbm.b.30412

Related Literature

Article Analysis
・Side Effects of dipyridamole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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