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Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task.

Author: Lima FerreiraTatiana, Menezes OliveiraMaria Gabriela, Monteiro MoreiraKarin, Perez FigueredoLarissa Zeggio, Vecchio FornariRaquel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

MK-801 potentiates the effects of dicyclomine on memory impairment in rats, suggesting that the M1-muscarinic receptor is involved in the synergistic interaction between cholinergic muscarinic and glutamatergic NMDA receptors.
Paper Details　
Original Abstract of the Article :
It has been demonstrated that MK-801 potentiates the effects of the non-selective muscarinic antagonist scopolamine on memory in rats. In this study, we investigated the role of the M1-muscarinic receptor in this interaction, by administering different doses of dicyclomine (DIC) and MK-801 in combin...See full text at original site
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引用元：
https://doi.org/10.1016/j.brainresbull.2005.07.019

データ提供：米国国立医学図書館（NLM）

Unveiling the Interplay of Brain Chemicals: M1-Muscarinic and NMDA Receptors

The brain is a complex network of interconnected pathways, where various neurotransmitters work together to regulate our thoughts, emotions, and behaviors. This study investigates the intricate interplay between two crucial neurotransmitter systems: the M1-muscarinic receptors and the glutamatergic NMDA receptors. The study's findings demonstrate that these two receptor systems work in concert, with the NMDA receptors potentiating the effects of the M1-muscarinic receptors on memory processes. This complex interplay highlights the delicate balance within the brain and the importance of understanding these interactions for developing effective therapeutic strategies.

Exploring the Brain's Intricate Communication System

This study provides valuable insights into the complex communication system within the brain. Understanding how different neurotransmitter systems interact is crucial for developing effective treatments for neurological disorders and enhancing cognitive function.

Unraveling the Mysteries of the Mind

Just as a camel navigates the vast desert with an intricate sense of direction, understanding the brain's intricate pathways is essential for navigating the mysteries of the mind. This study sheds light on the complex interplay between different neurotransmitter systems, providing a foundation for further exploration of the brain's remarkable capabilities.

Dr. Camel's Conclusion

The study on the interaction between M1-muscarinic and glutamatergic NMDA receptors sheds light on the intricate communication system within the brain. This understanding is crucial for developing effective treatments for neurological disorders and enhancing cognitive function.

Date :
  1. Date Completed 2005-12-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16216700

DOI: Digital Object Identifier

10.1016/j.brainresbull.2005.07.019

Related Literature

Article Analysis
・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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