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Focus on trial endpoints of clinical relevance and the use of almotriptan for the acute treatment of migraine.

Author: DahlöfC G, MathewN, NappiG, SandriniG

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Almotriptan is a 5-HT(1B/1D) receptor agonist used for the acute treatment of migraine. It has been shown to be effective and well tolerated in over 5,000 patients. Almotriptan has the highest sustained pain-free (SPF) rate and lowest adverse-event (AE) rate of all oral triptans.
Paper Details　
Original Abstract of the Article :
Almotriptan is a 5-HT(1B/1D) receptor agonist, or triptan, indicated for the acute treatment of migraine. It has been shown to be effective and well tolerated for the treatment of acute migraine in approximately 5000 patients enrolled in short-term placebo- and active-controlled trials and long-term...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.1368-5031.2005.00692.x

データ提供：米国国立医学図書館（NLM）

Focus on Clinical Relevance in Migraine Treatment: Almotriptan's Role

In the vast desert of migraine research, we strive to find oases of effective treatment. This study delves into the world of clinical trials, focusing on the crucial aspect of trial endpoints that are relevant to patients' lives. The authors explore the use of almotriptan, a triptan medication, for acute migraine treatment. They emphasize the importance of composite endpoints like 'sustained pain-free' (SPF) which incorporate key aspects that migraine sufferers value: complete pain relief, no recurrence, rapid onset, and minimal side effects.

Almotriptan: A Promising Oasis in the Migraine Desert?

Almotriptan has shown promising results in treating acute migraine, based on its efficacy and safety demonstrated in both short-term and long-term clinical trials. A meta-analysis highlights its superiority among oral triptans, boasting the highest SPF rate and lowest adverse event rate. These findings suggest that almotriptan could be a valuable tool for managing migraine attacks.

Living with Migraine: Choosing the Right Oasis

Migraine can be a debilitating condition, disrupting daily life like a sandstorm. Understanding the importance of composite endpoints like SPF allows patients to make informed choices about their treatment options. By focusing on clinically relevant outcomes, we can ensure that migraine therapies truly provide relief and improve the quality of life for those affected.

Dr.Camel's Conclusion

This study reminds us that in the vast desert of migraine research, we must navigate toward oases of clinical relevance. By focusing on composite endpoints that reflect patients' needs, we can identify therapies that truly improve their lives. Almotriptan emerges as a potential oasis, offering hope for those struggling with migraine. Let's continue exploring this desert, seeking further advancements in migraine management and finding more effective therapies.

Date :
  1. Date Completed 2006-03-02
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

16236092

DOI: Digital Object Identifier

10.1111/j.1368-5031.2005.00692.x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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