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In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles.

Author: ForrestM Laird, KwonGlen S, MalickA Waseem, WonChee-Youb

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed an injectable formulation of rapamycin using PEG-PCL micelles. The micelles were less than 100 nm in diameter and released rapamycin over several days, with no burst release. The addition of alpha-tocopherol slowed the release rate.
Paper Details　
Original Abstract of the Article :
An injectable formulation of rapamycin was prepared using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-PCL). Drug-loaded PEG-PCL micelles were prepared by a co-solvent extraction technique. Resulting PEG-PCL micelles were less than 100 nm in diamet...See full text at original site
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引用元：
https://doi.org/10.1016/j.jconrel.2005.10.008

データ提供：米国国立医学図書館（NLM）

Controlled Release of Rapamycin from Micelles: A Novel Delivery System

The field of drug delivery is like a vast desert, with researchers constantly seeking innovative ways to deliver medications effectively and safely. This study delves into the intriguing world of micelles, tiny structures that can encapsulate drugs and deliver them to their intended target. The researchers focused on a particular type of micelle, made from poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-PCL), and loaded it with rapamycin, a powerful mTOR inhibitor. Their objective was to create a controlled-release system for rapamycin, ensuring that the drug is released gradually over time, optimizing its therapeutic effect.

Micelles: A Tiny Oasis for Drug Delivery

Imagine these PEG-PCL micelles like tiny, protective oases in the vast desert of the body. The study showed that these micelles were effective at encapsulating rapamycin and releasing it slowly over several days. However, the presence of serum albumin, a protein naturally found in the blood, accelerated the release rate. The researchers then incorporated alpha-tocopherol, a form of vitamin E, into the micelles, which slowed the release of rapamycin in the presence of serum albumin.

Micelles: A Potential Solution for Drug Delivery Challenges

This research offers a promising avenue for improving drug delivery. The ability to control the release of rapamycin could potentially enhance its effectiveness while minimizing unwanted side effects. This approach could be particularly beneficial in treating conditions where sustained drug levels are essential for optimal outcomes.

Dr. Camel's Conclusion

This study, like a desert traveler discovering a hidden spring, demonstrates the potential of micelles for controlled drug delivery. By optimizing the release of rapamycin, researchers have taken a significant step towards improving treatment outcomes and enhancing patient care.

Date :
  1. Date Completed 2006-02-27
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

16298448

DOI: Digital Object Identifier

10.1016/j.jconrel.2005.10.008

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Languages

English

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