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Side effects during continuous epidural infusion of morphine and fentanyl.

Author: BerghausenE J, DumontS W, HeineM F, HuangK C, SchroederJ A, TsuedaK, VogelR L, WhiteM J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Continuous epidural fentanyl infusion was associated with less respiratory depression and nausea than continuous epidural morphine infusion in patients following hip or knee replacement surgery.
Paper Details　
Original Abstract of the Article :
Respiratory effects, nausea, somnolence, and pruritus were compared during a 48-hr period of continuous epidural morphine (n = 34) and fentanyl (n = 32) infusion in 66 patients following elective total replacement of the hip or knee joint. Respiratory effects were assessed by PaCO2. Side effects wer...See full text at original site
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引用元：
https://doi.org/10.1007/BF03008321

データ提供：米国国立医学図書館（NLM）

Continuous Epidural Infusion: Comparing Morphine and Fentanyl

This study investigates the effects of continuous epidural infusion of [morphine] and [fentanyl], commonly used analgesics for postoperative pain management. The researchers compared the respiratory effects, nausea, somnolence, and pruritus associated with each medication in patients undergoing elective total hip or knee replacement.

Different Side Effect Profiles for Morphine and Fentanyl

The study revealed distinct side effect profiles for morphine and fentanyl. Morphine was associated with a more prolonged elevation in PaCO2 (a measure of respiratory function) and more frequent and severe nausea. Fentanyl, on the other hand, did not significantly affect PaCO2 and induced less nausea, but somnolence persisted for a longer duration. These findings suggest that the choice of medication for continuous epidural infusion should be tailored to individual patient characteristics and the desired pain management approach.

Considerations for Postoperative Pain Management

The study underscores the importance of careful monitoring for side effects during continuous epidural infusion of opioids. The researchers' findings highlight the need to be aware of the potential for respiratory depression, nausea, and somnolence, particularly with morphine. This knowledge can guide healthcare providers in optimizing pain management strategies and minimizing the risk of complications.

Dr.Camel's Conclusion

This study provides a valuable comparison of the side effect profiles of morphine and fentanyl during continuous epidural infusion. The researchers' findings highlight the importance of understanding the unique characteristics of each medication and tailoring treatment decisions to individual patient needs. It's a reminder that effective pain management requires a nuanced approach that considers both the benefits and potential risks of different therapies.

Date :
  1. Date Completed 1992-09-09
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

1643680

DOI: Digital Object Identifier

10.1007/BF03008321

Related Literature

Article Analysis
・Side Effects of fentanyl
SNS
PICO Info
in preparation
Languages

English

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