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Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis.

Author: BoxallElizabeth H, BrokJesper, GluudChristian, GongYan, LeeChuanfang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Hepatitis B vaccine, hepatitis B immunoglobulin, and vaccine plus immunoglobulin prevent hepatitis B occurrence in newborn infants of mothers positive for hepatitis B surface antigen.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the effects of hepatitis B vaccine and immunoglobulin in newborn infants of mothers positive for hepatitis B surface antigen. DESIGN: Systematic review and meta-analysis of randomised clinical trials. DATA SOURCES: Electronic databases and hand searches. REVIEW METHODS: Ran...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1363909/

データ提供：米国国立医学図書館（NLM）

Protecting Newborns from Hepatitis B: A Comprehensive Approach

Hepatitis B, a viral infection that can cause serious liver damage, is a significant health concern worldwide. This research focuses on the crucial role of vaccination and immunoglobulin in protecting newborn infants from this potentially deadly disease. The authors, like explorers meticulously mapping a treacherous territory, conducted a systematic review and meta-analysis of randomized clinical trials to assess the effectiveness of different interventions.

Vaccination and Immunoglobulin: A Powerful Defense

The results clearly demonstrate the effectiveness of hepatitis B vaccine and immunoglobulin in preventing hepatitis B infection in newborns. The meta-analysis revealed that vaccination significantly reduced the occurrence of hepatitis B, with a relative risk of 0.28 compared to placebo. This finding, like a well-placed oasis in the desert, provides hope for protecting newborns from this serious threat. The study also found that the combination of vaccine and immunoglobulin offered the most effective protection, further emphasizing the importance of a multi-pronged approach to prevention.

A Vital Tool in the Fight Against Hepatitis B

This research underscores the importance of vaccination and immunoglobulin in protecting newborns from hepatitis B infection. These interventions provide a powerful defense against this potentially devastating disease. As a researcher, I am heartened by the progress made in protecting vulnerable populations, and I encourage all parents to ensure their newborns receive the recommended hepatitis B vaccinations.

Dr.Camel's Conclusion

This research, like a beacon of light guiding us through the darkness of infectious diseases, highlights the power of vaccination and immunoglobulin in protecting newborns from hepatitis B. It's a testament to the tireless work of medical professionals who dedicate their lives to improving global health.

Date :
  1. Date Completed 2006-02-16
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

16443611

DOI: Digital Object Identifier

PMC1363909

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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