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Antimuscarinic actions of antihistamines on the heart.

Author: FarleyJerry M, LiuHuiling, ZhengQi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the interaction of four antihistamines with muscarinic receptors. Fexofenadine and cetirizine had little or no interaction with muscarinic receptors.
Paper Details　
Original Abstract of the Article :
Antimuscarinic side-effects, which include dry mouth, tachycardia, thickening of mucus possibly sedation, of the antihistamines limited the usefulness of these drugs. The advent of newer agents has reduced the sedative effect of the antihistamine. The data presented here show that one of the newest ...See full text at original site
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引用元：
https://doi.org/10.1007/s11373-005-9053-7

データ提供：米国国立医学図書館（NLM）

Antihistamines and the Heart: A Tale of Muscarinic Interactions

This research explores the potential interactions of antihistamines, commonly used to treat allergies, with muscarinic receptors in the heart. The authors investigated the antimuscarinic actions of several antihistamines, finding that desloratadine and diphenhydramine, both first-generation antihistamines, exhibit competitive inhibition of muscarinic receptor-mediated slowing of the heart. In contrast, newer antihistamines such as cetirizine and fexofenadine did not interact with muscarinic receptors. The study's findings provide valuable insights into the potential cardiovascular effects of antihistamines and may guide the selection of specific drugs for patients with pre-existing heart conditions.

Navigating the Desert of Antihistamine Effects

The study demonstrates the potential for antihistamines to interact with muscarinic receptors in the heart, highlighting the need for careful consideration when prescribing these medications to individuals with pre-existing cardiovascular conditions. The study's findings provide valuable insights into the potential cardiovascular effects of antihistamines and may guide the selection of specific drugs for patients with pre-existing heart conditions.

Heart Health in the Desert: Choosing Antihistamines Wisely

Imagine a vast desert landscape, where the heart beats steadily amidst the heat and dryness. This study explores the potential impact of antihistamines on this delicate rhythm. The findings suggest that certain antihistamines can interact with muscarinic receptors in the heart, potentially influencing heart rate. Therefore, it is important to choose antihistamines carefully, especially for individuals with pre-existing heart conditions, to minimize potential cardiovascular effects.

Dr.Camel's Conclusion

This study investigates the antimuscarinic actions of antihistamines, revealing that certain first-generation antihistamines interact with muscarinic receptors in the heart. The findings provide valuable insights into the potential cardiovascular effects of antihistamines and may guide the selection of specific drugs for patients with pre-existing heart conditions.

Date :
  1. Date Completed 2006-08-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16453179

DOI: Digital Object Identifier

10.1007/s11373-005-9053-7

SNS
PICO Info
in preparation
Languages

English

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