Paper Details

  1. Home
  2. Paper Details

Hydralazine target: from blood vessels to the epigenome.

Author: ArceClaudia, CandelariaMyrna, Dueñnas-GonzalezAlfonso, Perez-CardenasEnrique, Segura-PachecoBlanca, Taja-ChayebLucia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Hydralazine, an antihypertensive drug primarily used for pregnancy-related hypertension, has shown potential as a cancer treatment. It can reactivate tumor suppressor genes silenced by methylation, a process linked to cancer. While hydralazine has a good safety profile from decades of use for hypertension, it can cause side effects like headache, nausea, and a lupus-like syndrome. It's currently in Phase II trials for various cancers, often combined with other therapies.
Paper Details　
Original Abstract of the Article :
Hydralazine was one of the first orally active antihypertensive drugs developed. Currently, it is used principally to treat pregnancy-associated hypertension. Hydralazine causes two types of side effects. The first type is an extension of the pharmacologic effect of the drug and includes headache, n...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413557/

データ提供：米国国立医学図書館（NLM）

Hydralazine: A Multifaceted Desert Wanderer

Hydralazine, a medication used to treat high blood pressure, has a fascinating history and a range of therapeutic applications. This study explores the multifaceted nature of hydralazine, examining its effects on blood vessels, DNA methylation, and even its potential as an anti-cancer agent. Imagine hydralazine as a desert wanderer with a diverse skillset, adept at navigating various terrains. Researchers delve into hydralazine's ability to relax blood vessels, its influence on DNA methylation, and its potential to reactivate tumor suppressor genes.

A Versatile Wanderer

The study highlights hydralazine's potential to target multiple pathways, suggesting that this medication could have wider applications in medicine.

Hydralazine: A Promising Agent

Ongoing research is exploring the potential of hydralazine for treating cancer and other conditions.

Dr.Camel's Conclusion

Hydralazine, like a skilled desert wanderer, navigates the complexities of the human body with remarkable versatility. This study reveals the potential of this medication for treating various conditions, offering hope for new therapeutic avenues and advancements in medicine.

Date :
  1. Date Completed 2006-04-26
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

16507100

DOI: Digital Object Identifier

PMC1413557

Related Literature

Article Analysis
・Side Effects of hydralazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.