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Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials.

Author: ChenJunmin, LiuChao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Sulfasalazine (SSZ) showed some benefit in reducing ESR and easing spinal stiffness in patients with AS, but no evidence of benefit in physical function, pain, spinal mobility, enthesitis, or patient and physician global assessment. SSZ might benefit patients at an early stage of disease, with higher level of ESR (or active disease) and peripheral arthritis.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy and toxicity of sulfasalazine (SSZ) for the treatment of ankylosing spondylitis (AS). METHODS: We searched randomized and quasi-randomized trials in any language comparing SSZ with placebo in treatment of AS. Two reviewers independently selected the studies and a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16583475

データ提供：米国国立医学図書館（NLM）

Sulfasalazine for Ankylosing Spondylitis: A Search for Relief in the Desert of Chronic Pain

Ankylosing spondylitis (AS), a chronic inflammatory disease primarily affecting the spine, is like a persistent desert wind, causing pain and stiffness that can significantly impact quality of life. This research investigates the efficacy of sulfasalazine (SSZ), a drug traditionally used for inflammatory bowel disease, in treating AS. It's like exploring a new oasis in the desert of chronic pain, seeking potential relief for this challenging condition.

Sulfasalazine: A Potential Solution in the Desert of AS

The study suggests that SSZ may have some benefits in reducing erythrocyte sedimentation rate (ESR), a marker of inflammation, and easing spinal stiffness in patients with AS. It's like finding a source of fresh water in a parched desert, offering a potential path to relief. However, the study also highlights the importance of considering potential side effects and the need for individualized treatment approaches. The researchers observed a higher rate of withdrawals due to side effects in the SSZ group compared to the placebo group, emphasizing the importance of careful monitoring and tailored treatment plans.

Ankylosing Spondylitis: Finding the Right Path to Management

This research highlights the importance of finding the right treatment for AS, much like navigating a complex desert landscape. The study suggests that SSZ may be a viable option for some patients, particularly those in the early stages of the disease with active inflammation and peripheral arthritis. However, it emphasizes the need for personalized treatment approaches and ongoing research to better understand the long-term efficacy and safety of this drug.

Dr.Camel's Conclusion

This research underscores the ongoing search for effective treatments for AS, a condition that continues to affect many individuals worldwide. It's a reminder that the field of medicine is constantly evolving, with new treatments and approaches emerging to address a wide range of health challenges. This research offers a valuable contribution to the ongoing quest for improved management and quality of life for individuals with AS.

Date :
  1. Date Completed 2006-05-09
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16583475

DOI: Digital Object Identifier

0315162X-33-722

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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