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Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis.

Author: , AchironAnat, BergJames E, DietrichDennis W, FletcherMalcolm, MandlerRaul N, MillerAriel, PanitchHillel S, PopeLaura E, SmithRichard A, ThistedRonald A, VollmerTimothy L, WymerJames P, WynnDaniel R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

DM/Q (dextromethorphan and quinidine) is beneficial in treating pseudobulbar affect in multiple sclerosis patients. DM/Q was associated with greater reductions in the Center for Neurologic Study-Lability Scale scores and fewer crying or laughing episodes. DM/Q was well tolerated, with dizziness being the most common side effect.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy and safety of DM/Q (capsules containing dextromethorphan [DM] and quinidine [Q]) compared with placebo, taken twice daily, for the treatment of pseudobulbar affect over a 12-week period in multiple sclerosis patients. METHODS: A total of 150 patients were randomi...See full text at original site
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引用元：
https://doi.org/10.1002/ana.20828

データ提供：米国国立医学図書館（NLM）

Pseudobulbar Affect: A Journey Through the Desert of Neurological Disorders

Pseudobulbar affect (PBA), a condition characterized by uncontrollable laughing or crying, can be a distressing symptom for individuals with neurological disorders. This research investigates the efficacy and safety of dextromethorphan/quinidine (DM/Q) in treating PBA in patients with multiple sclerosis.

The authors conduct a double-blind, placebo-controlled trial, meticulously comparing the effectiveness of DM/Q to placebo in a group of multiple sclerosis patients. This study, like a caravan traversing a challenging desert landscape, seeks to uncover a potential treatment for this debilitating symptom.

Navigating the Desert of Symptoms: Finding Relief for Pseudobulbar Affect

The study's results demonstrate that DM/Q effectively reduces the severity of PBA in patients with multiple sclerosis. This discovery offers hope for individuals struggling with this distressing symptom, potentially improving their quality of life and well-being.

A Desert of Possibilities: Expanding Treatment Options

This research expands the treatment options for PBA, offering a potential solution for individuals with multiple sclerosis who experience this debilitating symptom. It highlights the importance of exploring innovative therapies to address the diverse needs of patients with neurological disorders.

Dr.Camel's Conclusion

This study provides valuable evidence for the effectiveness of DM/Q in treating pseudobulbar affect in patients with multiple sclerosis. It underscores the importance of finding effective treatments for this distressing symptom, potentially improving quality of life and well-being for individuals with neurological disorders. As we continue to navigate the desert of neurological research, it's crucial to embrace innovation and explore new therapies that can enhance patient outcomes.

Date :
  1. Date Completed 2006-06-14
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

16634036

DOI: Digital Object Identifier

10.1002/ana.20828

Related Literature

Article Analysis
・Effects of dextromethorphan and quinidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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