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Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries.

Author: BaklanovD, LindnerV, MaciagT, MandinovL, MandinovaA, MoodieK L, RedicanF, SimonsM, ZhuangZ, de MuinckE D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study assessed the effect of tetrathiomolybdate (TTM), a copper chelator, on in-stent restenosis in pigs. TTM significantly inhibited in-stent restenosis by reducing neointimal hyperplasia.
Paper Details　
Original Abstract of the Article :
Stress-induced release of IL-1alpha and fibroblast growth factor-1 is dependent on intracellular copper and is a major driver of neointimal hyperplasia. Therefore, we assessed the effect of tetrathiomolybdate (TTM), a clinically proven copper chelator, on in-stent restenosis. Nine pigs were treated ...See full text at original site
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引用元：
https://doi.org/10.1152/ajpheart.00148.2006

データ提供：米国国立医学図書館（NLM）

Fighting In-Stent Restenosis with Copper Chelation

The field of cardiovascular medicine is always seeking new ways to prevent in-stent restenosis, a condition where arteries narrow after stent implantation. This study investigated the potential of a copper chelator, tetrathiomolybdate (TTM), to combat this problem. Their findings suggest that TTM might offer a novel approach to minimizing the risk of this common complication.

Copper Chelation: A Promising Strategy for In-Stent Restenosis

The study found that TTM significantly reduced in-stent restenosis in pigs, a model for human cardiovascular disease. This suggests that TTM, like a clever oasis-finder, can help prevent arteries from re-narrowing after stent implantation. The researchers found that TTM not only improved the artery's diameter but also reduced the formation of neointimal tissue, a major contributor to restenosis.

A New Approach to Preventing Restenosis

This study provides compelling evidence for the potential of copper chelation as a strategy to prevent in-stent restenosis. It opens the door to further research and clinical trials exploring the application of TTM in human patients. This research could lead to new ways to maintain the health of our arteries and prevent the need for repeat interventions.

Dr. Camel's Conclusion

This study, much like a refreshing oasis in the vast desert of cardiovascular disease, offers a promising new approach to combating the challenge of in-stent restenosis. It's a testament to the ongoing search for innovative solutions to improve heart health.

Date :
  1. Date Completed 2007-01-16
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

16731651

DOI: Digital Object Identifier

10.1152/ajpheart.00148.2006

SNS
PICO Info
in preparation
Languages

English

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