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Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity: demonstrable differences in vitro and clinically.

Author: FlintOliver P, MaaJen-Fue, NoorMustafa A, ParkerRex A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The HIV protease inhibitor (PI) atazanavir/ritonavir had significantly less effect on glucose metabolism than lopinavir/ritonavir in vitro and clinically. Atazanavir inhibited glucose uptake in vitro significantly less than lopinavir and ritonavir. In a randomized cross-over study, atazanavir/ritonavir did not significantly change insulin sensitivity, while lopinavir/ritonavir significantly decreased insulin sensitivity. The HOMA insulin resistance index significantly increased with both drug regimens but glucose area under the curve increased only with lopinavir/ritonavir.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The HIV protease inhibitor (PI) atazanavir does not impair insulin sensitivity acutely but ritonavir and lopinavir induce insulin resistance at therapeutic concentrations. OBJECTIVE: To test the hypothesis that atazanavir combined with a lower dose of ritonavir would have significantly ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/16954722

データ提供：米国国立医学図書館（NLM）

Investigating the Impact of Protease Inhibitors on Glucose Metabolism

This research delves into the intricate world of HIV treatment, exploring the impact of protease inhibitors (PIs) on glucose metabolism. The study, a combination of in vitro and clinical research, aims to understand the effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity. The findings reveal that both combinations can affect glucose metabolism, but atazanavir/ritonavir appears to have a less pronounced impact on insulin sensitivity compared to lopinavir/ritonavir.

Atazanavir/Ritonavir – A Potential Option for Managing Glucose Metabolism

The study reveals a significant finding – atazanavir/ritonavir appears to have a less detrimental effect on insulin sensitivity compared to lopinavir/ritonavir. This research suggests that atazanavir/ritonavir could be a potential option for managing glucose metabolism in individuals with HIV who require PI therapy, offering a path to minimizing the potential for metabolic complications.

Navigating the Landscape of HIV Treatment

This research highlights the importance of careful monitoring of glucose metabolism in individuals receiving PI therapy for HIV. Open communication with your healthcare provider about any potential side effects of your medication, including those that could affect glucose metabolism, is crucial for managing your health effectively. Remember, like navigating a desert with shifting sands, managing HIV requires a proactive and informed approach, working closely with your healthcare team to optimize your treatment plan.

Dr.Camel's Conclusion

This research sheds light on the differential effects of protease inhibitor combinations on glucose metabolism, suggesting that atazanavir/ritonavir might be a preferable option for managing glucose metabolism in individuals with HIV who require PI therapy. This study encourages further investigation into the metabolic effects of different PI combinations, ultimately aiming to improve the long-term health outcomes for individuals with HIV.

Date :
  1. Date Completed 2007-02-05
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

16954722

DOI: Digital Object Identifier

00002030-200609110-00004

SNS
PICO Info
in preparation
Languages

English

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