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Development of safer molecules through chirality.

Author: KothekarM A, PatilP A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the pharmacokinetic and pharmacodynamic implications of chirality in drug development, focusing on the benefits of replacing racemates with single enantiomers. It highlights successful chiral switches, such as levosalbutamol, S-ketamine, and levocetirizine, which have led to improved safety and efficacy profiles compared to their racemic counterparts.
Paper Details　
Original Abstract of the Article :
Many of the drugs currently used in medical practice are mixtures of enantiomers (racemates). Many a times, the two enantiomers differ in their pharmacokinetic and pharmacodynamic properties. Replacing existing racemates with single isomers has resulted in improved safety and/or efficacy profile of ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/17006031

データ提供：米国国立医学図書館（NLM）

Chirality: A Key to Safer Medications

Many medications are like a mixture of sand and salt: they consist of two mirror-image molecules called enantiomers. This research explores the importance of chirality, the property of a molecule that distinguishes its mirror images. It emphasizes that understanding chirality is crucial for developing safer and more effective medications.

The Importance of Enantiomer Purity

The researchers highlight that even though enantiomers are mirror images, they can have very different effects in the body, much like how different types of sand can behave differently in the desert. This research emphasizes the importance of developing medications with single isomers, or pure enantiomers, to improve safety and efficacy.

A Camel's Perspective on Safer Medications

This research underscores the importance of understanding the subtle differences within molecules. It's a reminder that even the tiniest details can have a significant impact, much like how a small shift in the desert sand can alter the path of a camel caravan. Developing medications with pure enantiomers holds great potential for improving patient outcomes, making it a crucial area for continued research.

Dr. Camel's Conclusion

Understanding chirality is key to developing safer and more effective medications. By focusing on single isomers, we can potentially avoid unwanted side effects and maximize the positive impacts of medication. This research is a valuable reminder that understanding the intricate details of molecules is essential for improving human health.

Date :
  1. Date Completed 2007-06-07
  2. Date Revised 2022-02-11
Further Info :

Pubmed ID

17006031

DOI: Digital Object Identifier

17006031

SNS
PICO Info
in preparation
Languages

English

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