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Treatment of cutaneous T-cell lymphoma with retinoids.

Author: DuvicMadeleine, ZhangChunlei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Retinoids have been used for years in the treatment of cutaneous T-cell lymphomas (CTCL), with bexarotene being the first synthetic retinoid X receptor retinoid approved by the Food and Drug Administration for CTCL. Future research will focus on strategies to decrease side effects, identify novel receptor subtype-selective retinoids, and explore synergistic combination therapies.
Paper Details　
Original Abstract of the Article :
Retinoids are biologic regulators of differentiation, proliferation, apoptosis, and immune response. Retinoids (all-trans retinoic acid, 13-cis-retinoic acid, and the synthetic analogs isotretinoin, etretinate, and acitretin) have been used for years as monotherapy and/or in combination for treatmen...See full text at original site
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引用元：
https://doi.org/10.1111/j.1529-8019.2006.00083.x

データ提供：米国国立医学図書館（NLM）

Retinoids: A Light in the Desert of Cutaneous T-Cell Lymphoma

Cutaneous T-cell lymphoma (CTCL) is a type of skin cancer that can be challenging to treat. This article, published in Seminars in Oncology, reviews the use of retinoids, a class of vitamin A derivatives, for the treatment of CTCL. The authors discuss the various retinoids that have been used to treat CTCL, highlighting their mechanisms of action and clinical efficacy. It's like discovering a new oasis in the desert, offering a potential source of relief for those battling this disease.

Retinoids: A Multifaceted Approach

The article emphasizes the multifaceted nature of retinoids, highlighting their ability to regulate cell growth, differentiation, and apoptosis. These properties make retinoids a promising therapeutic strategy for CTCL, which is characterized by abnormal growth and proliferation of T cells. It's like having a multi-tool in the desert, where each tool can be used to address a different challenge.

Retinoids: A Path to Improvement

This article underscores the ongoing efforts to improve the treatment of CTCL. The authors highlight the need for further research to develop new and more effective retinoids with improved therapeutic profiles. It's a reminder that the journey to finding effective cancer treatments is a continuous exploration, requiring ongoing research and innovation. Just as a camel adapts to the harsh desert environment, we must adapt our approach to cancer treatment to meet the challenges of this complex disease.

Dr.Camel's Conclusion

This review provides a comprehensive overview of the use of retinoids for the treatment of cutaneous T-cell lymphoma, highlighting their potential benefits and ongoing research efforts. It's a testament to the ongoing quest for better cancer treatments, a journey that requires perseverance, innovation, and a commitment to improving patient outcomes.

Date :
  1. Date Completed 2007-01-09
  2. Date Revised 2007-12-03
Further Info :

Pubmed ID

17014481

DOI: Digital Object Identifier

10.1111/j.1529-8019.2006.00083.x

SNS
PICO Info
in preparation
Languages

English

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