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5-HT (serotonin) physiology and related drugs.

Author: GershonM D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Serotonin (5-HT) plays a crucial role in the gut’s ability to mediate reflexes without input from the brain or spinal cord. 5-HT is secreted by enterochromaffin cells and activates both intrinsic and extrinsic primary afferent neurons. Abnormal enteric release or inactivation of 5-HT is associated with irritable bowel syndrome (IBS). A potent 5-HT(3) antagonist, such as alosetron, can prevent both visceral hypersensitivity and abnormal motility in IBS patients. 5-HT also functions as a growth factor in the development of enteric neurons. Drugs that interfere with 5-HT should be used with caution during pregnancy.
Paper Details　
Original Abstract of the Article :
Alone among organs of the body, the gut is able to mediate reflexes in the absence of input from the brain or spinal cord. This ability appears to be caused by the secretion of serotonin (5-HT) by enterochromaffin (EC) cells of the mucosal epithelium. This 5-HT is secreted into the wall of the gut, ...See full text at original site
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引用元：
https://doi.org/10.1097/00001574-200003000-00004

データ提供：米国国立医学図書館（NLM）

Serotonin: The Unsung Hero of the Gut

The gastrointestinal tract, a fascinating organ system, is capable of orchestrating reflexes independently of the brain and spinal cord. This intriguing ability is attributed to the secretion of serotonin (5-HT) by enterochromaffin (EC) cells within the mucosal epithelium. This research delves into the intricate role of 5-HT in regulating gut function, highlighting its involvement in peristalsis, secretion, and signaling to the central nervous system.

Serotonin and Gut Health: A Delicate Balance

The authors explore the potential role of 5-HT in the pathogenesis of irritable bowel syndrome (IBS). They propose that aberrant release or inactivation of 5-HT may contribute to visceral hypersensitivity and abnormal motility in IBS. Interestingly, they also discovered that 5-HT acts as a growth factor during enteric neuronal development, emphasizing its multifaceted role in the gut.

A Desert Oasis of Gut Health: Tips for a Healthy Gut

Like a desert oasis, maintaining a healthy gut is crucial for overall well-being. This research underscores the importance of understanding the delicate balance of serotonin in the gut and its potential implications for gut health. Strategies to support gut health include a balanced diet, stress management, and regular exercise.

Dr.Camel's Conclusion

Serotonin, often associated with mood, plays a critical role in the intricate workings of the gut. This research sheds light on the complex interplay between serotonin and gut health, highlighting the potential implications for conditions like IBS. Understanding the importance of serotonin in the gut can guide us towards promoting healthy digestion and overall well-being.

Date :
  1. Date Completed 2007-07-03
  2. Date Revised 2019-11-10
Further Info :

Pubmed ID

17024028

DOI: Digital Object Identifier

10.1097/00001574-200003000-00004

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Languages

English

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