Do antibiotics contribute to postoperative ileus? Contractile responses of ileum smooth muscle in Guinea pigs to long-term parenteral ceftriaxone and ampicillin.

Author: ArpacikMehmet, BagcivanIhsan, CeranCanan, KaradasBaris, KayaTijen, SaracBülent

Paper Details 
Original Abstract of the Article :
Antibiotics may impair small bowel smooth muscle contractility and contribute to postoperative ileus. The aim of this study was to compare the contractile responses of ileum smooth muscle to different agonists in guinea pigs treated with ceftriaxone (Rocephin; F. Hoffman-La Roche, Kaiseraugst, Switz...See full text at original site
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引用元:
https://doi.org/10.1111/j.1445-2197.2006.03922.x

データ提供:米国国立医学図書館(NLM)

Antibiotics and Postoperative Ileus: Exploring the Link

The world of surgery, like a vast desert, often presents unexpected challenges. This study investigates the potential link between antibiotics and postoperative ileus, a condition characterized by delayed bowel function after surgery. The researchers examined the contractile responses of ileum smooth muscle in guinea pigs treated with either ceftriaxone or ampicillin, two commonly used antibiotics. This study explores the potential impact of antibiotics on intestinal motility, providing valuable insights into the complex interplay between medication and surgical outcomes.

Antibiotics and Intestinal Motility: Exploring the Relationship

The study reveals that long-term parenteral ceftriaxone treatment in guinea pigs significantly impairs ileum smooth muscle contractility compared to ampicillin. This finding suggests a potential mechanism by which antibiotics may contribute to postoperative ileus. This discovery is like uncovering a hidden path in the desert of surgical research, shedding light on the potential influence of antibiotics on intestinal function. Further investigation is needed to confirm these findings in human subjects and explore potential interventions to mitigate the negative effects of antibiotics on intestinal motility.

Navigating the Desert of Surgical Recovery: Considerations for Antibiotics

This research highlights the importance of carefully considering the use of antibiotics in surgical settings, particularly regarding their potential impact on intestinal motility. It's like navigating a complex desert, where choosing the right path is crucial for a successful journey. Understanding the potential link between antibiotics and postoperative ileus allows healthcare professionals to make more informed decisions about antibiotic use and explore alternative strategies to promote smooth recovery.

Dr. Camel's Conclusion

This study is a reminder of the complexities within the desert of medical research, where even seemingly straightforward solutions, like antibiotics, can have unexpected consequences. The findings suggest a potential link between ceftriaxone and impaired intestinal motility, highlighting the importance of further research to better understand the impact of antibiotics on surgical recovery. This study encourages a more nuanced approach to antibiotic use, recognizing the potential for both benefits and risks.

Date :
  1. Date Completed 2007-01-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17054555

DOI: Digital Object Identifier

10.1111/j.1445-2197.2006.03922.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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